Alex Zhavoronkov

Insilicos (United States) — United States

Computer Science · Physical Sciences

70h-index18.2kcitations441works12.02yr avg
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Research Topics

Computational Drug Discovery Methods(66), Genetics, Aging, and Longevity in Model Organisms(51), Machine Learning in Materials Science(27), Bioinformatics and Genomic Networks(26), Health, Environment, Cognitive Aging(22)

Publications440 total

Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart
2026· 1 citedOpen Access
Delphi-derived Framework for Healthspan-Oriented Care: The Cardiometabolic Health Perspective
SSRN Electronic Journal·2026Open Access
Recent advance in macrocyclic CDK inhibitors
Future Medicinal Chemistry·2025Open Access
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
arXiv (Cornell University)·2025Open Access
Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors
Journal of Medicinal Chemistry·2025· 1 cited
Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
Nature Communications·2025· 4 citedOpen Access
Discovery and Biological Evaluation of Novel, Potent, and Orally Available CBLB Inhibitors
Journal of Medicinal Chemistry·2025
Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses
Scientific Reports·2025Open Access
The Right to Be Remembered: Preserving Maximally Truthful Digital Memory in the Age of AI
arXiv (Cornell University)·2025Open Access
Modelling sex differences of neurological disorders in vitro
Nature Reviews Bioengineering·2025· 2 cited
GENESIS-IPF: PHASE 2A COHORT CHARACTERISTICS AND LUNG IMAGING INDICATE CORRELATES OF RESPONSE TO ISM001-055 (RENTOSERTIB) IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS
CHEST Journal·2025
Comparison of the baseline clinical and HRCT characteristics of Insilico’s ISM001_055 phase 2a trial cohort in China with real-world IPF datasets
2025
Rentosertib, a generative AI-discovered TNIK inhibitor improves lung function in IPF patients
2025
<scp>AlphaFold</scp> Kinase Optimizer: Enhancing Virtual Screening Performance Through Automated Refinement of <scp>AlphaFold</scp> ‐Based Kinase Structures
Proteins Structure Function and Bioinformatics·2025
Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors
Journal of Medicinal Chemistry·2025
Bridging Physics and Aging Biology: Insights from the First Physics in Aging Biology Workshop
2025Open Access
A novel, covalent and highly synthetically accessible SARS-CoV-2 Mpro chloroacetamide inhibitor
2025
Traf2- and Nck-interacting kinase inhibitors: a patent review (2008–2024)
Expert Opinion on Therapeutic Patents·2025
Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis
Aging·2025· 1 citedOpen Access
Author response for "AlphaFold Kinase Optimizer: Enhancing Virtual Screening Performance Through Automated Refinement of AlphaFold-Based Kinase Structures"
2025
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Frequent Co-authors

Polina Mamoshina(15), Alexander Aliper(14), Alex Aliper(13), Alexey Moskalev(10), Daniil Polykovskiy(9), Quentin Vanhaelen(9), Vladimir Aladinskiy(8), Evgeny Putin(8), Ivan V. Ozerov(8), Yan A. Ivanenkov(7), Artem V. Artemov(5), Vadim N. Gladyshev(5), Anton Buzdin(5), Bogdan Zagribelnyy(4), Artur Kadurin(4), Brian K. Kennedy(4), Mikhail Shaposhnikov(4), Arie Budovsky(4), Vadim E. Fraifeld(4), Mikhail Korzinkin(4)