Séverine Wack

Université Paris-Sud — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index797citations23works0.02yr avg
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Research Topics

RNA Interference and Gene Delivery(7), Cancer Research and Treatments(7), Virus-based gene therapy research(6), Nanoparticle-Based Drug Delivery(4), Pancreatic and Hepatic Oncology Research(4)

Publications23 total

A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity
Proceedings of the National Academy of Sciences·2014· 202 citedOpen Access
Improving the Antitumor Activity of Squalenoyl‐Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene
Advanced Healthcare Materials·2012· 57 cited
Design, optimization and in vitro evaluation of reverse micelle-loaded lipid nanocarriers containing erlotinib hydrochloride
International Journal of Pharmaceutics·2012· 71 cited
Interaction of an amphiphilic squalenoyl prodrug of gemcitabine with cellular membranes
European Journal of Pharmaceutics and Biopharmaceutics·2011· 25 cited
Squalenoyl Gemcitabine Monophosphate: Synthesis, Characterisation of Nanoassemblies and Biological Evaluation (Eur. J. Org. Chem. 14/2011)
European Journal of Organic Chemistry·2011· 1 cited
Squalenoyl Gemcitabine Monophosphate: Synthesis, Characterisation of Nanoassemblies and Biological Evaluation
European Journal of Organic Chemistry·2011· 28 cited
New potent anticancer nanoassembly from squalenoylation platform: doxorubicin derivative.
2011
Squalenoyl nucleoside monophosphate nanoassemblies: New prodrug strategy for the delivery of nucleotide analogues
Bioorganic & Medicinal Chemistry Letters·2010· 35 cited
Thérapie génique d'un adenocarcinome pancréatique par ciblage de l'expression de la purine nucléoside phosphorylase d' e. coli a l'aide d'un promoteur de marqueur tumoral
2008
Telomerase Transcriptional Targeting of Inducible Bax/TRAIL Gene Therapy Improves Gemcitabine Treatment of Pancreatic Cancer
Molecular Therapy·2007· 16 citedOpen Access
Efficient electrogene therapy for pancreatic adenocarcinoma treatment using the bacterial purine nucleoside phosphorylase suicide gene with fludarabine
International Journal of Oncology·2007· 22 citedOpen Access
K‐ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment
Cancer Science·2007· 88 citedOpen Access
Valproic acid induces non-apoptotic cell death mechanisms in multiple myeloma cell lines
International Journal of Oncology·2007· 40 citedOpen Access
Efficacité des gènes proaptotiques : trail-bax sur des modèles de cancer du pancréas : visualisation par imagerie moléculaire
Gastroentérologie Clinique et Biologique·2005
Etude de modalités multithérapeutiques et diagnostiques appliquées au cancer du pancréas
Serveur des thèses de l'Université de Strasbourg (University of Strasbourg)·2005· 1 cited
Transcriptional tumor‐selective promoter targeting of <i>E. coli</i> purine nucleoside phosphorylase for pancreatic cancer suicide gene therapy
The Journal of Gene Medicine·2004· 17 cited
Efficacité de la stratégie des gènes suicides introduits par électroporation pour traiter l’adénocarcinome pancréatique
Gastroentérologie Clinique et Biologique·2004
Étude du phénomène d’hypoxie sur des modèles de cancers de pancréas
Gastroentérologie Clinique et Biologique·2004
Comparaison de deux stratégies d’inhibition de K-Ras : les oligonucléotides antisens et les RNA interfèrents dans des modèles de cancer pancréatique humain
Gastroentérologie Clinique et Biologique·2004
Suicide Gene/Prodrug Therapy for Pancreatic Adenocarcinoma by E. Coli Purine Nucleoside Phosphorylase and 6-Methylpurine 2′-deoxyriboside
Pancreas·2004· 18 cited
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Frequent Co-authors

Amor Hajri(13), Marc Aprahamian(13), Patrick Couvreur(7), Sophie J. Deharvengt(7), Claudie Bourgaux(5), Didier Desmaële(5), L. Harivardhan Reddy(4), Élise Lepeltier(4), Joachim Caron(4), Sinda Lepêtre‐Mouelhi(4), Soukaina Réjiba(3), Andrei Maksimenko(2), Franco Dosio(2), Annalisa Ferrero(2), Barbara Stella(2), Luigi Cattel(2), Jacques Marescaux(2), Julie Mougin(1), Andrée-Anne Weyn(1), Cindy Meyer(1)