Lynda K. Doolittle

Marine Biological Laboratory — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index3.2kcitations30works5.12yr avg
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Research Topics

Genomics and Chromatin Dynamics(14), Cellular Mechanics and Interactions(9), RNA Research and Splicing(9), Chromosomal and Genetic Variations(5), Microtubule and mitosis dynamics(5)

Publications30 total

Multiscale structure of chromatin condensates explains phase separation and material properties
Science·2025· 6 citedOpen Access
Multiscale structure of chromatin condensates explains phase separation and material properties.
Apollo (University of Cambridge)·2025Open Access
An electrostatic repulsion model of centromere organisation
2025· 2 citedOpen Access
Nucleosome spacing can fine-tune higher-order chromatin assembly
Nature Communications·2025· 11 citedOpen Access
Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography
Proceedings of the National Academy of Sciences·2025· 9 citedOpen Access
BPS2025 - Nucleosome spacing can fine-tune higher-order chromatin assembly
Biophysical Journal·2025
BPS2025 - Nucleosome spacing can fine-tune higher-order chromatin assembly
Biophysical Journal·2025
Multi-scale structure of chromatin condensates rationalizes phase separation and material properties
2025· 10 citedOpen Access
Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly
2024· 8 citedOpen Access
Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography
2024· 5 citedOpen Access
In diverse conditions, intrinsic chromatin condensates have liquid-like material properties
Proceedings of the National Academy of Sciences·2023· 75 citedOpen Access
A mitotic chromatin phase transition prevents perforation by microtubules
Nature·2022· 110 citedOpen Access
In Diverse Conditions Intrinsic Chromatin Condensates Have Liquid-like Material Properties
2021· 7 citedOpen Access
A chromatin phase transition protects mitotic chromosomes against microtubule perforation
2021· 6 citedOpen Access
Organization of Chromatin by Intrinsic and Regulated Phase Separation
Cell·2019· 1.1k citedOpen Access
Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation
2019· 20 citedOpen Access
Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites
eLife·2017· 171 citedOpen Access
Author response: Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites
2017· 2 citedOpen Access
Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation
eLife·2013· 112 citedOpen Access
Author response: Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation
2013· 1 citedOpen Access
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Frequent Co-authors

Michael K. Rosen(26), Bryan A. Gibson(13), Shae B. Padrick(8), Sy Redding(7), Maria Julia Maristany(7), Jorge R. Espinosa(7), Rosana Collepardo‐Guevara(7), Daniel W. Gerlich(6), Claudia Blaukopf(5), Lifeng Chen(5), Jan Huertas(5), Huabin Zhou(5), Joshua Hutchings(5), Momoko Shiozaki(5), Margot Riggi(5), David L. Garbers(4), Chad A. Brautigam(4), Stephen E. Farr(4), Xiaowei Zhao(4), Zhiheng Yu(4)