Zhexing Wen

Universidad del Desarrollo — Chile

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index10.3kcitations136works3.52yr avg
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Research Topics

Genetics and Neurodevelopmental Disorders(20), Congenital heart defects research(15), Epigenetics and DNA Methylation(13), Pluripotent Stem Cells Research(13), Neurogenesis and neuroplasticity mechanisms(12)

Publications136 total

Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome
Frontiers in Psychiatry·2026Open Access
scCotag: Diagonal integration of single-cell multi-omics data via prior-informed co-optimal transport and regularized barycentric mapping
2025Open Access
Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer’s Disease
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Integrative transcriptomics and network analysis reveals core genes driving meningioma pathogenesis and clinical outcomes
Scientific Reports·2025Open Access
A non-coding RNA risk pathway in schizophrenia: miR-137 enhances the lncRNA GOMAFU through a pathological transcription network
Translational Psychiatry·2025Open Access
TMOD-06. Brain metastasis–induced neuroglial disruption: insights from a novel human organoid–brain slice co-culture model
Neuro-Oncology·2025
Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk
Advanced Science·2025Open Access
Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits
PLoS Computational Biology·2025· 1 citedOpen Access
Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease
Brain Behavior & Immunity - Health·2025Open Access
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology
Nature Communications·2025· 6 citedOpen Access
Multi-omics analysis reveals aspirin is associated with reduced risk of Alzheimer’s disease
2025· 1 citedOpen Access
1158 Medically Refractory Epilepsy in Tuberous Sclerosis Necessitating Surgery: Electrophysiological, Morphological, and Spatial Assessment of Tubers Demonstrates Neurofilament Deposition in Epileptogenic Foci
Neurosurgery·2025
167 COVID-19 Variants and Infection Rates of Neurons, Astrocytes, and Microglia in the Human Brain Demonstrate Direct Viral Replication Within Parenchymal Cells Causing Neurological Symptoms
Neurosurgery·2025
508 The Largest Patient-Derived Meningioma Organoid Bank Demonstrates a Robust Model for Transcriptional Analysis of Tumors
Neurosurgery·2025
202 Glioblastoma Organoid (GBO) invasion of Prolonged Ex Vivo Human Brain Slices: Spatial Transcriptomics Reveals GBO Modulation of Ionotropic Glutamate Receptors, Inducing Neuronal Excitotoxicity
Neurosurgery·2025
Targeting the SFRP1 Interaction with ADAM10 for Therapeutic Discovery in Alzheimer's Disease (Abstract ID: 159943)
Journal of Pharmacology and Experimental Therapeutics·2025
Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology
Cancers·2025· 1 citedOpen Access
Immunodepletion of amyloid‐associated matrisomal proteins reduces Aβ in hiPSC‐derived neurons
Alzheimer s & Dementia·2024Open Access
Longitudinal multi-omics reveals pathogenic <i>TSC2</i> variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex
2024· 4 citedOpen Access
Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids
Scientific Reports·2024· 13 citedOpen Access
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Frequent Co-authors

Guo‐li Ming(23), Hongjun Song(16), Kimberly M. Christian(14), Peng Jin(9), Chongchong Xu(8), Hengli Tang(7), Gary J. Bassell(7), James Q. Zheng(7), Xuyu Qian(6), Ki‐Jun Yoon(6), Sarah C. Ogden(5), Christy Hammack(5), Bing Yao(5), Yujing Li(5), Hao Wu(5), Emily M. Lee(5), Sinead M. O’Donovan(5), Robert E. McCullumsmith(5), Ha Nam Nguyen(4), Fadi Jacob(4)