Christopher P. Regan

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

24h-index2.7kcitations92works3.42yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(32), Ion channel regulation and function(14), Neuropeptides and Animal Physiology(10), Cardiac Arrhythmias and Treatments(10), Migraine and Headache Studies(9)

Publications92 total

Regulatory safety pharmacology & toxicology assessment studies: Measurement of the ECG and hemodynamic parameters in non-rodent species
Journal of Pharmacological and Toxicological Methods·2025
Characterization of a human wearable ECG device for continuous in-cage data collection in non-rodents
Journal of Pharmacological and Toxicological Methods·2025
Abstract Fri099: Improved Translation of Cardiac Sodium Channel Inhibition to In Vivo QRS Interval Prolongation via the hIPSC Cardiomyocyte Model
Circulation Research·2025
Improved translation of Nav1.5 channel inhibition to in vivo QRS interval prolongation via the hIPSC cardiomyocyte model
Journal of Pharmacological and Toxicological Methods·2025· 1 cited
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non–rodent species in regulatory safety assessment studies
Journal of Pharmacological and Toxicological Methods·2025· 2 cited
Characterization of a human wearable ECG device for continuous data collection in freely moving non-rodents
Journal of Pharmacological and Toxicological Methods·2025· 1 cited
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species
Journal of Pharmacological and Toxicological Methods·2025
Recommendations on the measurement of electrocardiogram and hemodynamic parameters in restrained non-rodent species in regulatory safety assessment studies
Journal of Pharmacological and Toxicological Methods·2025· 1 cited
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis
Journal of Pharmacological and Toxicological Methods·2025
Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues
Bioorganic & Medicinal Chemistry Letters·2024· 2 cited
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments
Journal of Pharmacological and Toxicological Methods·2024· 4 cited
Autonomic Dysfunction Linked to Inhibition of the Na <sub>v</sub> 1.7 Sodium Channel
Circulation·2024· 16 citedOpen Access
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Journal of Medicinal Chemistry·2024· 6 citedOpen Access
Pharmacologic characterization of atogepant: A potent and selective calcitonin gene–related peptide receptor antagonist
Cephalalgia·2024· 18 citedOpen Access
Discovery of Sulfone Containing Metallo-B-Lactamase Inhibitors with Reduced Bacterial Cell Efflux and Histamine Release Issues
SSRN Electronic Journal·2024Open Access
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis
Journal of Pharmacological and Toxicological Methods·2023· 3 cited
Development and characterization of canine‐specific computational models to predict pulsatile arterial hemodynamics and ventricular‐arterial coupling
Physiological Reports·2023· 2 citedOpen Access
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Channels·2022· 3 citedOpen Access
Virtual Health in Patient Care and Clinical Research
Health informatics·2022
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain
Journal of Medicinal Chemistry·2021· 21 citedOpen Access
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Frequent Co-authors

Joseph J. Lynch(24), Gary L. Stump(12), Stefanie A. Kane(10), Hillary Regan(8), Gary K. Owens(7), Rebecca B. White(7), Pierre Morissette(7), Frederick Sannajust(6), Andrew Danziger(5), Christopher J. Dinsmore(5), Jixin Wang(4), Robert H. Spencer(4), Nigel J. Liverton(4), Charles McIntyre(4), George D. Hartman(4), Christopher Salvatore(4), Eric L. Moore(4), Chi‐Chung Li(4), Ian M. Bell(4), Kathleen H. Berecek(4)