Nigel Barrass

AstraZeneca (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index1.0kcitations21works0.02yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(4), Cancer-related Molecular Pathways(4), Pharmacogenetics and Drug Metabolism(3), Drug Transport and Resistance Mechanisms(3), RNA Interference and Gene Delivery(3)

Publications21 total

Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
Xenobiotica·2014· 17 cited
AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis
Clinical Cancer Research·2007· 355 citedOpen Access
A first-in-man phase I tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor AZD5438 in healthy male volunteers
Cancer Chemotherapy and Pharmacology·2006· 29 cited
AZD1152: A highly potent and specific aurora kinase inhibitor.
Cancer Research·2006· 6 cited
Toxicity testing in the development of anticancer drugs
The Lancet Oncology·2002· 9 cited
Cell Proliferation in the Liver and Thyroid of C57B1/10J Mice after Dietary Administration of Chlordane
Environmental Health Perspectives·1993· 2 citedOpen Access
Cell proliferation in the liver and thyroid of C57Bl/10J mice after dietary administration of chlordane.
Environmental Health Perspectives·1993· 19 citedOpen Access
Phenobarbital-induced hepatocellular proliferation: anti-bromodeoxyuridine and anti-proliferating cell nuclear antigen immunocytochemistry.
Journal of Histochemistry & Cytochemistry·1993· 47 citedOpen Access
Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methylclofenapate and clofibric acid in rat liver
Carcinogenesis·1993· 61 cited
<i>C‐myc</i> expression is maintained during the G<sub>1</sub> phase cell cycle block produced by beryllium
Cell Proliferation·1991· 5 cited
Analysis of the Ha-<i>ras</i> oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylintrosamine or phenobarbitone
Carcinogenesis·1991· 40 cited
Cellular and molecular effects of di-n-octyltin dichloride on the rat thymus
International Journal of Immunopharmacology·1989· 13 cited
From genes to clones: Introduction to gene technology
Food and Chemical Toxicology·1989· 2 cited
Response of c-myc Expression to the Toxic Insult of Beryllium
Human Toxicology·1988
Activation of ras oncogene in aflatoxin-induced rat liver carcinogenesis.
Proceedings of the National Academy of Sciences·1988· 72 citedOpen Access
Oncogenes and growth control
Food and Chemical Toxicology·1987· 7 cited
Activation of N-<i>ras</i> in a Human Melanoma Cell Line
Molecular and Cellular Biology·1985· 80 citedOpen Access
Activation of N-ras in a human melanoma cell line.
Molecular and Cellular Biology·1985· 58 cited
A novel transforming gene in a human malignant melanoma cell line
Nature·1984· 136 cited
The effect of ultrasound and hyperthermia on sister chromatid exchange and division kinetics of BHK 21 C13/A3 cells.
PubMed·1982· 14 cited
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Frequent Co-authors

Rose Ann Padua(3), Roger J. Price(3), Robert W. Wilkinson(2), Rajesh Odedra(2), Simon P. Heaton(2), Stephen R. Wedge(2), Nicholas Keen(2), John R. Foster(2), Madeleine C. Brady(2), Kevin M. Foote(2), Nicola M. Heron(2), Frédéric Jung(2), Andrew Mortlock(2), Stephen Green(2), G A Currie(2), T.C. Orton(2), D.A. Jackson(2), Alan Marsden(2), David N. Skilleter(2), Claire Crafter(1)