John F. Hancock

The University of Texas Health Science Center at Houston — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

84h-index27.4kcitations281works1.32yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(105), Cellular transport and secretion(63), Lipid Membrane Structure and Behavior(46), Caveolin-1 and cellular processes(38), Erythrocyte Function and Pathophysiology(30)

Publications281 total

eIF2B Selectively Anchors and Activates Mutant KRAS
2025
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors
iScience·2025Open Access
Terraforming the KRAS lipid landscape
Nature Chemical Biology·2025Open Access
MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids
The Journal of Cell Biology·2024· 4 cited
Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors
Journal of the American Chemical Society·2024· 5 citedOpen Access
Abstract 1215: DIRAS3 inhibits oncogenic RAS signaling and RAS-dependent cell growth driven by prevalent KRAS hot spot mutations
Cancer Research·2024
Author Reply to Peer Reviews of Myotubularin-related proteins regulate KRAS function by controlling plasma membrane levels of polyphosphoinositides and phosphatidylserine
2024
MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids
2024· 1 citedOpen Access
Cellular responses after (neratinib plus pemetrexed) exposure in NSCLC cells
Anti-Cancer Drugs·2023· 2 cited
Direct Modulators of K-Ras–Membrane Interactions
ACS Chemical Biology·2023· 23 citedOpen Access
Supplemental Figures 1-10 from Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer
2023Open Access
Supplementary Figure 2 from Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy
2023Open Access
Supplementary Figure Legend from Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy
2023Open Access
Data from Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer
2023Open Access
Supplementary Figure 1 from Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy
2023Open Access
Data from Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer
2023Open Access
Supplementary Text and Legends from Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer
2023Open Access
Supplementary Figure Legend from Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy
2023Open Access
Supplementary Figure 1 from Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy
2023Open Access
Supplementary Text and Legends from Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer
2023Open Access
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Frequent Co-authors

Robert G. Parton(20), Ian A. Prior(8), Sarah J. Plowman(7), Alemayehu A. Gorfe(7), Yong Zhou(6), Daniel Abankwa(5), Karen A. Cadwallader(4), Piers J. Walser(4), Cornelia Muncke(4), Angus Harding(4), Michael Hanzal‐Bayer(4), Barak Rotblat(4), Yoel Kloog(4), Hugh Paterson(3), Michelle M. Hill(3), Robert Luetterforst(3), Matthew Kirkham(3), Susan J. Nixon(3), Sandrine Roy(3), Ann Apolloni(3)