Joseph T. Bruder

Regenxbio (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index4.7kcitations65works5.02yr avg
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Research Topics

Virus-based gene therapy research(24), RNA Interference and Gene Delivery(13), Viral Infectious Diseases and Gene Expression in Insects(12), Mosquito-borne diseases and control(9), Melanoma and MAPK Pathways(9)

Publications65 total

The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cellular Immunology·2024· 5 cited
Characterization and biodistribution of under-employed gene therapy vector AAV7
Journal of Virology·2023· 6 citedOpen Access
In silico prediction and in vivo testing of promoters targeting GABAergic inhibitory neurons
Molecular Therapy — Methods & Clinical Development·2023· 3 citedOpen Access
Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors
Frontiers in Neurology·2022· 33 citedOpen Access
Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy
International Journal of Molecular Sciences·2022· 26 citedOpen Access
Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity
Molecular Therapy — Methods & Clinical Development·2021· 29 citedOpen Access
Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome
Neurobiology of Disease·2020· 29 citedOpen Access
Liver-Targeted AAV8 Gene Therapy Ameliorates Skeletal and Cardiovascular Pathology in a Mucopolysaccharidosis IVA Murine Model
Molecular Therapy — Methods & Clinical Development·2020· 31 citedOpen Access
Role of the Raf Signal Transduction Pathway in Fos/Jun Regulation and Determination of Cell Fates
2017· 1 cited
Profiling the Targets of Protective CD8+ T Cell Responses to Infection
Molecular Therapy — Methods & Clinical Development·2017· 4 citedOpen Access
New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model
Malaria Journal·2017· 17 citedOpen Access
A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates
PLoS ONE·2013· 49 citedOpen Access
Human adenovirus 5-vectored<i>Plasmodium falciparum</i>NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection
Human Vaccines & Immunotherapeutics·2013· 37 citedOpen Access
Identification of a Suppressor Mutation That Improves the Yields of Hexon-Modified Adenovirus Vectors
Journal of Virology·2013· 10 citedOpen Access
Adenoviruses isolated from wild gorillas are closely related to human species C viruses
Virology·2013· 23 cited
DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity
PLoS ONE·2013· 139 citedOpen Access
Correction: Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses
PLoS ONE·2012· 8 citedOpen Access
Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses
PLoS ONE·2012· 41 citedOpen Access
Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults
PLoS ONE·2011· 70 citedOpen Access
Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component
PLoS ONE·2011· 80 citedOpen Access
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Frequent Co-authors

Imre Kovesdi(13), Ulf R. Rapp(11), Thomas L. Richie(11), Keith Limbach(9), Noelle B. Patterson(8), Denise L. Doolan(8), Martha Sedegah(7), C. Richter King(7), Esteban Abot(6), Michael R. Hollingdale(6), Thomas J. Wickham(5), Ilin Chuang(5), Cindy Tamminga(5), Harini Ganeshan(5), María Belmonte(5), Fouzia Farooq(5), Nancy Richie(5), Meng Shi(5), Christian F. Ockenhouse(5), Ping Chen(5)