Deborah Silvera

New York University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index1.6kcitations20works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(7), Viral Infections and Immunology Research(4), Cancer, Lipids, and Metabolism(4), Cancer-related molecular mechanisms research(3), RNA Research and Splicing(3)

Publications20 total

mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells
Molecular and Cellular Biology·2016· 43 citedOpen Access
Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy
Clinical Breast Cancer·2015· 54 citedOpen Access
Abstract PD5-6: Sustained hyperactivated mTOR & JAK2/STAT3 pathways in inflammatory breast cancer (IBC): Evidence for mTOR plus JAK2 therapeutic targeting
Cancer Research·2013
Hyperactivated mTOR and JAK2/STAT3 pathways: Crucial molecular drivers and potential therapeutic targets of inflammatory breast cancer (IBC).
Journal of Clinical Oncology·2013· 1 cited
Hyperactivated mTOR and JAK2/STAT3 pathways: Crucial molecular drivers and potential therapeutic targets of inflammatory breast cancer (IBC).
Journal of Clinical Oncology·2013
Abstract P5-03-02: Targeting mRNA Translation to Enhance the Radiosensitivity of Inflammatory Breast Cancer Stem Cells
Cancer Research·2012
Atypical ezrin localization as a marker of locally advanced breast cancer
Breast Cancer Research and Treatment·2012· 22 cited
mTORC1/2 kinase inhibition in an animal model of endometrial cancer
Gynecologic Oncology·2012
TORC1/2 Inhibition with Concurrent Radiation Controls Inflammatory Breast Cancer in a Preclinical Animal Model Through Selective Blockade of Translation
International Journal of Radiation Oncology*Biology*Physics·2011· 1 citedOpen Access
Over-expression of Translation Initiation Factor eIF4G Confers Robust Radioresistance to the Cancer Stem Cell Population in Inflammatory Breast Cancer
International Journal of Radiation Oncology*Biology*Physics·2011
Abstract P5-06-05: Catalytic mTOR Inhibition with pp242 but Not Allosteric Inhibition with Rapamycin RAD001 Enhances the Radiosensitivity of Inflammatory Breast Cancer in an Animal Model
Cancer Research·2010
Inflammatory Breast Cancer Radio-resistance and its Cancer Stem Cell Population are Oppositely Controlled by Translation Factor eIF4G
International Journal of Radiation Oncology*Biology*Physics·2010· 1 cited
Translational control in cancer
Nature reviews. Cancer·2010· 804 cited
Inflammatory breast cancer cells are constitutively adapted to hypoxia
Cell Cycle·2009· 54 citedOpen Access
Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer
Nature Cell Biology·2009· 243 cited
Effect of Ku proteins on IRES‐mediated translation
Biology of the Cell·2006· 14 citedOpen Access
The N-terminal K Homology Domain of the Poly(rC)-binding Protein Is a Major Determinant for Binding to the Poliovirus 5′-Untranslated Region and Acts as an Inhibitor of Viral Translation
Journal of Biological Chemistry·1999· 71 citedOpen Access
Intracellular determinants of picornavirus replication
Trends in Microbiology·1999· 92 cited
Toward a poliovirus-based simian immunodeficiency virus vaccine: correlation between genetic stability and immunogenicity
Journal of Virology·1997· 48 citedOpen Access
Engineering poliovirus as a vaccine vector for the expression of diverse antigens
Science·1994· 143 cited

Frequent Co-authors

Robert J. Schneider(15), Silvia C. Formenti(7), Rezina Arju(7), Eileen P. Connolly(6), Farbod Darvishian(5), Judith D. Goldberg(5), Tsivia Hochman(5), Shah Giashuddin(5), Paul H. Levine(4), Raul Andino(4), Komal Jhaveri(4), Eleonora Teplinsky(4), Yasmeen Sarfraz(4), T. Venuto(4), Melissa Alexander(3), Salman Hashmi(3), Heather J. Hoffman(3), Baljit Singh(3), Amanda Valeta(3), Michelle L. Badura(3)