János G. Filep

Hôpital Maisonneuve-Rosemont — Canada

Immunology and Microbiology · Life Sciences

64h-index11.3kcitations272works3.02yr avg
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Research Topics

Neutrophil, Myeloperoxidase and Oxidative Mechanisms(54), Nitric Oxide and Endothelin Effects(50), Immune Response and Inflammation(50), Renin-Angiotensin System Studies(41), Cell Adhesion Molecules Research(28)

Publications272 total

Intrarenal renin–angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes
Clinical Science·2026Open Access
Taming neutrophil extravasation: a promising therapeutic approach to dampen inflammation?
Haematologica·2025Open Access
Renal Tubule-Specific Deletion of Angiotensinogen Gene Ameliorates Tubulopathy via Attenuation of Mitochondrial Dysfunction and Senescence in Akita Mouse Kidneys
Journal of the American Society of Nephrology·2025
Editorial: Targeting the interleukin-1β/interleukin-6/C-reactive protein pathway in clinical medicine - a road map to clinical trial design
Frontiers in Cardiovascular Medicine·2025Open Access
Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes
2025Open Access
Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes
2025Open Access
Renal Tubule–Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes
Diabetes·2025· 6 citedOpen Access
Deletion of Angiotensinogen in Renal Tubule Attenuates Diabetic Kidney Disease Progression in Diabetic Mice
Journal of the American Society of Nephrology·2024
Deletion of Angiotensinogen in Renal Tubules Attenuates Tubular Senescence in Diabetic Kidney Disease
Journal of the American Society of Nephrology·2024
WCN24-1234 RENAL TUBULE-SPECIFIC NRF2 DELETION ATTENUATES GLOMERULAR HYPERFILTRATION AND KIDNEY INJURY VIA DOWN-REGULATION OF SGLT2 AND ANGIOTENSINOGEN EXPRESSION IN DIABETIC MICE
Kidney International Reports·2024Open Access
Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair
American Journal of Physiology-Cell Physiology·2024· 27 citedOpen Access
Renal Tubule-Specific Angiotensinogen Knockout Ameliorates Diabetic Kidney Disease in Type 1 Diabetic Akita Mice
Journal of the American Society of Nephrology·2023
Renal Tubule-Specific NRF2 Deletion Downregulates SGLT2 and Angiotensinogen Expression and Ameliorates GFR and Kidney Injury in Akita Mice
Journal of the American Society of Nephrology·2023
NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells
Antioxidants·2023· 22 citedOpen Access
Resolvin D4 disengages emergency granulopoiesis
Blood·2023Open Access
C-reactive protein: a target for therapy to reduce inflammation
Frontiers in Immunology·2023· 135 citedOpen Access
Two to tango: endothelial cell TMEM16 scramblases drive coagulation and thrombosis
Journal of Clinical Investigation·2023· 6 citedOpen Access
Editorial: Lactate metabolism and regulation of the immune response
Frontiers in Immunology·2022· 2 citedOpen Access
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions
EMBO Molecular Medicine·2022· 12 citedOpen Access
Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy
Antioxidants·2022· 109 citedOpen Access
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Frequent Co-authors

John S.D. Chan(15), Driss El Kebir(13), Levente József(11), Julie R. Ingelfinger(11), Shao‐Ling Zhang(9), Lawrence A. Potempa(8), Christine Zouki(8), Tarek Khreiss(7), Charles N. Serhan(6), Nicos A. Petasis(5), Isabelle Chénier(5), Meriem Sekheri(5), Wanling Pan(4), Marie-Luise Brezniceanu(4), Yi Wu(3), Tusty‐Jiuan Hsieh(3), Nicolas Godin(3), Alain Fournier(3), Shiow‐Shih Tang(2), F. Liu(2)