Xiyun Chai

AbbVie (United States) — United States

Medicine · Health Sciences

11h-index5.8kcitations24works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(17), Dementia and Cognitive Impairment Research(11), Neuroscience and Neuropharmacology Research(2), Functional Brain Connectivity Studies(2), Migraine and Headache Studies(2)

Publications24 total

Validation and pre-analytical considerations for processing cerebrospinal fluid samples on a high-throughput proximity extension assay platform
2025Open Access
Author Response to Comment on “Plasma calcitonin gene‐related peptide and nerve growth factor as headache and pain biomarkers in recently deployed soldiers with and without a recent concussion”
Headache The Journal of Head and Face Pain·2024
Plasma calcitonin gene–related peptide and nerve growth factor as headache and pain biomarkers in recently deployed soldiers with and without a recent concussion
Headache The Journal of Head and Face Pain·2023· 11 citedOpen Access
Evaluation of Plasma Calcitonin Gene-Related Peptide as a Biomarker for Painful Temporomandibular Disorder and Migraine
Journal of Pain Research·2023· 8 citedOpen Access
Phospho‐tau217 and phospho‐tau181 in plasma and CSF as biomarkers for Alzheimer’s disease
Alzheimer s & Dementia·2020· 6 citedOpen Access
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders
JAMA·2020· 1.4k citedOpen Access
Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease
Science Advances·2020· 347 citedOpen Access
Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
Nature Communications·2020· 437 citedOpen Access
Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia
Nature Medicine·2020· 1.2k cited
Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration
Nature Medicine·2020· 767 citedOpen Access
Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
2020· 35 citedOpen Access
Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease
EMBO Molecular Medicine·2019· 346 citedOpen Access
P4‐540: CSF PTAU‐217 PERFORMS BETTER THAN PTAU‐181 IN DETECTING ABNORMAL RETENTION OF <sup>18</sup>F‐FLORTAUCIPIR AND DISCRIMINATING ALZHEIMER'S DISEASE FROM OTHER NEURODEGENERATIVE DISORDERS
Alzheimer s & Dementia·2019
O2‐05‐04: PLASMA PTAU181 LEVELS REFLECT [18F]AV1451 TAU PET UPTAKE ACROSS THE TAUOPATHY SPECTRUM
Alzheimer s & Dementia·2019Open Access
Plasma phospho‐tau181 increases with Alzheimer's disease clinical severity and is associated with tau‐ and amyloid‐positron emission tomography
Alzheimer s & Dementia·2018· 643 cited
P3‐075: The Relationship of TAU Pathology and Extracellular TAU in the Brains of TG4510 Mice
Alzheimer s & Dementia·2016· 1 cited
P3‐071: Exploring AV1451 Binding Through Biochemical and Biophysical Analysis of PHF TAU From Human and TG4510 Brains with Electron Microscopy
Alzheimer s & Dementia·2016Open Access
calcitonin gene-related peptide (CGRP) levels are elevated in the plasma and knee synovial fluid of patients with knee osteoarthritis (OA)
Osteoarthritis and Cartilage·2016· 5 citedOpen Access
P4–314: A vast difference in the levels of insoluble tau in commonly used tau mouse models
Alzheimer s & Dementia·2013Open Access
Constitutive secretion of tau protein by an unconventional mechanism
Neurobiology of Disease·2012· 234 citedOpen Access
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Frequent Co-authors

Jeffrey L. Dage(14), Nicholas K. Proctor(8), Oskar Hansson(8), Sebastian Palmqvist(7), Shorena Janelidze(7), Erik Stomrud(7), Niklas Mattsson(7), Ruben Smith(7), Kaj Blennow(6), David Airey(6), Henrik Zetterberg(5), John R. Sims(4), Geidy E. Serrano(3), Olof Strandberg(3), Thomas G. Beach(3), Eric M. Reiman(3), Sergey Shcherbinin(3), Gil D. Rabinovici(3), Su Wu(3), Kirk W. Johnson(3)