Charis Eng

Cleveland Clinic — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

139h-index73.9kcitations1.2kworks3.62yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(306), BRCA gene mutations in cancer(125), Genetic factors in colorectal cancer(106), Cancer Genomics and Diagnostics(89), Adrenal and Paraganglionic Tumors(82)

Publications1.2k total

Atypical Inter-Brain Synchrony and Social Communication Deficits in Girls with Fragile X Syndrome: Evidence from Functional Near-infrared Spectroscopy Hyperscanning
2025Open Access
Neurodevelopmental and Neurologic Manifestations of <i>PTEN</i> Hamartoma Tumor Syndrome
Neurology Genetics·2025Open Access
Targeted RNA sequencing of thyroid tumors from individuals with PTEN hamartoma tumor syndrome reveals a unique transcriptome with a predominantly RAS-like expression profile
Surgery·2025Open Access
Retraction: Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal-Like Sequences for Nuclear Import Mediated by Major Vault Protein
Cancer Research·2025Open Access
Editor’s Note: Nuclear-Cytoplasmic Partitioning of Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Differentially Regulates the Cell Cycle and Apoptosis
Cancer Research·2025Open Access
Altered Primary Somatosensory Neuron Development in a <i>Pten</i> Heterozygous Model for Autism Spectrum Disorder
Autism Research·2025· 1 citedOpen Access
The new microbiome on the block: challenges and opportunities of using human tumor sequencing data to study microbes
Nature Methods·2025· 7 citedOpen Access
Which Score for What? Operationalizing Standardized Cognitive Test Performance for the Assessment of Change
American Journal on Intellectual and Developmental Disabilities·2025· 2 citedOpen Access
Neurobehavioral Signatures in Overgrowth Intellectual Disability Syndromes: Dissecting Genotype-Phenotype Relationships in the PI3K-AKT-MTOR Pathway
2025· 1 citedOpen Access
Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction
Structure·2025Open Access
Genomic diversity in functionally relevant genes modifies neurodevelopmental versus neoplastic risks in individuals with germline PTEN variants
npj Genomic Medicine·2025· 3 citedOpen Access
Data from Cancer and Overgrowth Manifestations of &lt;i&gt;PTEN&lt;/i&gt; Hamartoma Tumor Syndrome: Management Recommendations from the International PHTS Consensus Guidelines Working Group
2025Open Access
Supplementary Table S1 from Cancer and Overgrowth Manifestations of &lt;i&gt;PTEN&lt;/i&gt; Hamartoma Tumor Syndrome: Management Recommendations from the International PHTS Consensus Guidelines Working Group
2025Open Access
Supplementary Table S2 from Cancer and Overgrowth Manifestations of &lt;i&gt;PTEN&lt;/i&gt; Hamartoma Tumor Syndrome: Management Recommendations from the International PHTS Consensus Guidelines Working Group
2025Open Access
Genotype-specific neoplastic risk profiles in patients with VHL disease
Endocrine Related Cancer·2025Open Access
Cell-free DNA Fragmentomics and Second Malignant Neoplasm Risk in Patients with PTEN Hamartoma Tumor Syndrome
Zenodo (CERN European Organization for Nuclear Research)·2025Open Access
Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
Nature Immunology·2025Open Access
Extended spectrum of cancers in PTEN hamartoma tumor syndrome
npj Precision Oncology·2025· 9 citedOpen Access
Morphological and functional differences between hippocampal and cortical microglia and its impact on neuronal over-excitation in a germline Pten mutant mouse model
Neuroscience·2025· 2 cited
Divergent PTEN–p53 interaction upon DNA damage in a human thyroid organoid model with germline PTEN mutations
Endocrine Related Cancer·2025· 1 citedOpen Access
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Frequent Co-authors

Patricia L. M. Dahia(6), Deborah J. Marsh(5), Ramon Parsons(5), Lois M. Mulligan(5), Hartmut P.H. Neumann(4), Bruce A.J. Ponder(4), Zimu Zheng(3), Catherine S. Healey(3), Emily Gardner(3), Margaret A. Ponder(3), Sarah R. McWhinney(3), Anne‐Paule Gimenez‐Roqueplo(3), Lauri A. Aaltonen(3), Paul Komminoth(3), George L. Mutter(3), Danny Liaw(2), Steven I. Wang(2), John B. Kwok(2), Oliver Gimm(2), Andrzej Januszewicz(2)