John Kuriyan

Vanderbilt University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

110h-index50.9kcitations404works4.52yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(79), Enzyme Structure and Function(49), Monoclonal and Polyclonal Antibodies Research(46), Protein Structure and Dynamics(44), Chronic Myeloid Leukemia Treatments(40)

Publications403 total

BPS2026 – Modularity within the DNA clamp loader complex
Biophysical Journal·2026
BTK autoinhibition analyzed by high-throughput swaps of SH2 domains
Proceedings of the National Academy of Sciences·2025Open Access
Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib
Science Signaling·2025· 1 cited
BTK Autoinhibition Analyzed by High-Throughput SH2 Domain Swaps
2025· 1 citedOpen Access
Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines
Science Signaling·2025· 4 citedOpen Access
Reactive oxygen species control protein degradation at the mitochondrial import gate
Molecular Cell·2024· 31 citedOpen Access
Autophosphorylation of the oncogenic protein TEL-ABL confers resistance to the allosteric ABL inhibitor asciminib
2024Open Access
Ligand‐induced <scp>CaMKIIα</scp> hub Trp403 flip, hub domain stacking, and modulation of kinase activity
Protein Science·2024· 6 citedOpen Access
Overcoming clinical BCR-ABL1 compound mutant resistance with combined ponatinib and asciminib therapy
Cancer Cell·2024· 11 citedOpen Access
A fluorescence‐based sensor for calibrated measurement of protein kinase stability in live cells
Protein Science·2024Open Access
Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition
2024· 1 citedOpen Access
Adaptive Capacity of a DNA Polymerase Clamp-loader ATPase Complex
Molecular Biology and Evolution·2024· 2 citedOpen Access
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
Nature Structural & Molecular Biology·2024· 1 citedOpen Access
A Fluorescence-Based Sensor for Calibrated Measurement of Protein Kinase Stability in Live Cells
2023· 1 citedOpen Access
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments
Immunity·2023· 24 citedOpen Access
Adaptive capacity of a DNA polymerase clamp-loader ATPase complex
2023Open Access
Conditional Requirement for Dimerization of the Membrane-Binding Module of BTK
2023Open Access
Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis
PLoS ONE·2023· 5 citedOpen Access
Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
eLife·2023· 15 citedOpen Access
Supplementary Table 1 from Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations
2023Open Access
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Frequent Co-authors

Bhushan Nagar(5), Martin Karplus(4), Morgan Huse(4), Frank Sicheri(4), Mike O’Donnell(4), Yibing Shan(4), David E. Shaw(4), Thomas H. Schindler(3), William G. Bornmann(3), Philip A. Cole(3), Ismail Moarefi(3), Matthew A. Young(3), Giulio Superti‐Furga(3), Angus C. Nairn(3), Dafna Bar‐Sagi(3), Natalia Jura(3), Nicholas Endres(3), Rahul Das(3), David E. Wemmer(3), Anton Arkhipov(3)