Barry M. Forman

City Of Hope National Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

52h-index20.5kcitations88works0.02yr avg
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Research Topics

Estrogen and related hormone effects(27), Drug Transport and Resistance Mechanisms(25), Peroxisome Proliferator-Activated Receptors(19), Retinoids in leukemia and cellular processes(17), Nuclear Receptors and Signaling(13)

Publications87 total

Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease
Bioorganic & Medicinal Chemistry·2021· 5 citedOpen Access
Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ
Bioorganic & Medicinal Chemistry·2017· 21 citedOpen Access
Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease
Bioorganic & Medicinal Chemistry·2016· 29 citedOpen Access
Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists
Bioorganic & Medicinal Chemistry·2015· 32 citedOpen Access
Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor
Bioorganic & Medicinal Chemistry·2014· 33 citedOpen Access
Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery
Bioorganic & Medicinal Chemistry·2013· 23 citedOpen Access
Bioimaging Real-Time PXR-Dependent mdr1a Gene Regulation in mdr1a.fLUC Reporter Mice
Journal of Pharmacology and Experimental Therapeutics·2013· 15 citedOpen Access
An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR)
Steroids·2012· 22 cited
Deficiency of G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Enhances Chemically Induced Liver Carcinogenesis
Hepatology·2012· 46 citedOpen Access
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice
Hepatology·2012· 143 cited
Tu1862 TGR5 Signaling Protects Against Inflammatory Bowel Diseases Through Antagonizing NF-κB Signaling and Reactive Oxygen Species Generation
Gastroenterology·2012
Specific bile acids inhibit hepatic fatty acid uptake in mice
Hepatology·2012· 76 cited
Hepatocarcinogenesis in FXR−/− Mice Mimics Human HCC Progression That Operates through HNF1α Regulation of FXR Expression
Molecular Endocrinology·2012· 108 citedOpen Access
FXR Protects Lung from Lipopolysaccharide-Induced Acute Injury
Molecular Endocrinology·2011· 39 citedOpen Access
The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice
Hepatology·2011· 449 citedOpen Access
Abstract 701: A mechanistic study of mdr1a gene regulation in vivo using bioimaging
Cancer Research·2011
Insufficient bile acid signaling impairs liver repair in CYP27−/− mice
Journal of Hepatology·2011· 41 cited
FXR Regulates Liver Repair after CCl4-Induced Toxic Injury
Molecular Endocrinology·2010· 108 citedOpen Access
Farnesoid X Receptor Alleviates Age-Related Proliferation Defects in Regenerating Mouse Livers by Activating Forkhead Box M1b Transcription
Hepatology·2009· 112 citedOpen Access
Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor
PLoS ONE·2009· 204 citedOpen Access
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Frequent Co-authors

Ronald M. Evans(13), Herbert H. Samuels(13), Jasmine Chen(11), Isabelle Dussault(8), Wendong Huang(6), Min Lin(6), Yan‐Dong Wang(5), Kevin Hollister(4), Donna Yu(4), Juan Casanova(4), Peter Tontonoz(3), Regina P. Brun(3), Bruce M. Spiegelman(3), Bruce Blumberg(3), Kazuhiko Umesono(3), Wei‐Dong Chen(3), David D. Moore(3), Mark A. Sherman(3), Nian Liu(3), Gregory A. Brent(3)