J. Silvio Gutkind

University of San Diego — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

140h-index66.4kcitations1.3kworks2.12yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(174), Protein Kinase Regulation and GTPase Signaling(171), Cancer-related Molecular Pathways(104), Receptor Mechanisms and Signaling(104), Cancer-related gene regulation(92)

Publications1.3k total

Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs
Cancer Prevention Research·2025Open Access
Protein kinase a regulates cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP
Journal of Biological Chemistry·2025Open Access
Supplementary Table S3 from A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
2025Open Access
Supplementary Table S1 from A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
2025Open Access
Supplementary Table S2 from A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
2025Open Access
Supplementary Figure from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer
2025Open Access
Supplementary Data from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer
2025Open Access
Supplementary figures S1-S5 from Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in <i>PIK3CA</i>- and <i>HRAS</i>-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity
2025Open Access
871 Immune architecture by design: chemokines as tools to sculpt the immune composition of solid tumors
Regular and Young Investigator Award Abstracts·2025Open Access
489 Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma
Regular and Young Investigator Award Abstracts·2025Open Access
676 Lymphatic-sparing immunoradiotherapy reprograms migratory dendritic cells to drive tumor rejection via the sentinel lymph node
Regular and Young Investigator Award Abstracts·2025Open Access
Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy
Advanced Science·2025· 1 citedOpen Access
LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
Cancer Research·2025· 2 cited
PROTACs in cancer immunotherapy: a minireview
Biochemical Society Transactions·2025Open Access
Chemokine-chemokine receptor networks in conventional type I dendritic cells: an opportunity to prime and boost anticancer immunity
Journal of Pharmacology and Experimental Therapeutics·2025· 1 citedOpen Access
Inhibition of anti-apoptotic BCL2 overcomes adaptive resistance to co-targeting of the protein kinase FAK and MEK in GNAQ-driven uveal melanoma
Journal of Biological Chemistry·2025· 1 citedOpen Access
Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinoma
2025Open Access
Noncanonical Pathways of Proteasome Inhibition in HPV‐Negative Head & Neck Cancer
Molecular Carcinogenesis·2025Open Access
Figure S1 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer
2025Open Access
Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer
2025Open Access
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Frequent Co-authors

Vyomesh Patel(10), Omar A. Coso(5), Hidemi Teramoto(5), James F. Rusling(5), Piero Crespo(4), Alfredo Molinolo(4), Julie Gavard(3), Rogério M. Castilho(3), Ramiro Iglesias‐Bartolomé(3), José P. Vaqué(3), Akrit Sodhi(3), Cristina Murga(3), M Chiariello(2), Ningzhi Xu(2), Toru Miki(2), Kenneth M. Yamada(2), Maria Domenica Castellone(2), Bart O. Williams(2), Ashwin Bhirde(2), Carlos Bais(2)