Charles R. Iden

Copenhagen University Hospital — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.6kcitations69works6.52yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(26), DNA Repair Mechanisms(11), Mass Spectrometry Techniques and Applications(11), Nephrotoxicity and Medicinal Plants(10), Advanced biosensing and bioanalysis techniques(8)

Publications69 total

DNA methylation markers for sensitive detection of circulating tumor DNA in patients with gastroesophageal cancers
ESMO Gastrointestinal Oncology·2024· 1 citedOpen Access
Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin
Journal of Biological Chemistry·2024· 12 citedOpen Access
Abstract 4660: Molecular mechanisms by which a bioactivated human carcinogen is transported to target tissues
Tumor Biology·2019Open Access
Abstract 4660: Molecular mechanisms by which a bioactivated human carcinogen is transported to target tissues
Cancer Research·2019
Abstract 5241: Using affinity probes to explore the nephrotoxicity of aristolochic acid
Cancer Research·2017
Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and<i>N</i>-hydroxyaristolactam I in human cells
Carcinogenesis·2016· 20 citedOpen Access
Impact of thymine glycol damage on <scp>DNA</scp> duplex energetics: Correlations with lesion‐induced biochemical and structural consequences
Biopolymers·2015· 11 cited
Total Synthesis of the Aristolochic Acids, Their Major Metabolites, and Related Compounds
Chemical Research in Toxicology·2014· 21 citedOpen Access
Bioactivation of the human carcinogen aristolochic acid
Carcinogenesis·2014· 61 citedOpen Access
Biomonitoring of Aristolactam-DNA Adducts in Human Tissues Using Ultra-Performance Liquid Chromatography/Ion-Trap Mass Spectrometry
Chemical Research in Toxicology·2012· 94 cited
Metabolic activation of aristolochic acid and mechanism of repair of aristolactam-DNA adducts in human cells
Research Center for Eco-Environmental Sciences OpenIR (Chinese Academy of Sciences)·2012
Aristolochic Acid I Metabolism in the Isolated Perfused Rat Kidney
Chemical Research in Toxicology·2011· 30 cited
Impact of α‐hydroxy‐propanodeoxyguanine adducts on DNA duplex energetics: Opposite base modulation and implications for mutagenicity and genotoxicity
Biopolymers·2009· 21 citedOpen Access
DNA adducts of aristolochic acid II: total synthesis and site-specific mutagenesis studies in mammalian cells
Nucleic Acids Research·2009· 88 citedOpen Access
Synthesis of the PhIP Adduct of 2‘-Deoxyguanosine and Its Incorporation into Oligomeric DNA
Chemical Research in Toxicology·2006· 16 cited
Proteomic Approach to Identification of Proteins Reactive for Abasic Sites in DNA
Molecular & Cellular Proteomics·2006· 28 citedOpen Access
Analysis of Steroid Conjugates in Sewage Influent and Effluent by Liquid Chromatography−Tandem Mass Spectrometry
Analytical Chemistry·2005· 144 cited
Incorporation of <i>N</i><sup>2</sup>-Deoxyguanosine Metabolic Adducts of 2-Aminonaphthalene and 2-Aminofluorene into Oligomeric DNA
Chemical Research in Toxicology·2005· 15 cited
Changes in Plasma Membrane Properties and Phosphatidylcholine Subspecies of Insect Sf9 Cells Due to Expression of Scavenger Receptor Class B, Type I, and CD36
Journal of Biological Chemistry·2004· 48 citedOpen Access
Stereoselective excision of thymine glycol lesions by mammalian cell extracts
DNA repair·2003· 21 cited
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Frequent Co-authors

Francis Johnson(23), Robert Rieger(17), Arthur P. Grollman(10), Radha Bonala(9), Maria Cecília de Araújo Rodrigues Torres(8), P. Lee Ferguson(5), Bruce J. Brownawell(5), Sivaprasad Attaluri(5), Viktoriya S. Sidorenko(3), Kathleen G. Dickman(3), Conceição A.S.A. Minetti(3), David P. Remeta(3), Kenneth J. Breslauer(3), J. R. Grover(3), Dmitry O. Zharkov(2), Thomas A. Rosenquist(2), Masaaki Moriya(2), Ирина Зайцева(2), Monica McTigue(2), Shinya Shibutani(2)