Chengfeng Merriman

Boston University — United States

Medicine · Health Sciences

11h-index358citations22works1.32yr avg
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Research Topics

Pancreatic function and diabetes(13), Diabetes and associated disorders(10), Trace Elements in Health(5), Diabetes Treatment and Management(4), Diabetes Management and Research(3)

Publications22 total

Detection of Anti-drug Antibodies (ADAs) to an Antibody-drug Conjugate (ADC) PYX-201 in Human Plasma Using a Novel Electrochemiluminescence (ECL) Immunoassay
Current Analytical Chemistry·2025· 1 cited
567 PYX-106, a highly differentiated anti-Siglec-15 monoclonal antibody, reverses Siglec-15 mediated immune suppression and enhances cytotoxic activity in human lymphocytes
Regular and Young Investigator Award Abstracts·2024· 1 citedOpen Access
Abstract 742: PYX-201, a stroma-targeting ADC composed of an anti-EDB+FN antibody conjugated to Auristatin0101, demonstrates strong anti-tumor efficacy across multiple human cancer indications in pre-clinical PDX tumor models
Cancer Research·2024· 2 cited
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Diabetes·2022· 3 citedOpen Access
A cell-surface autoantibody targets zinc transporter-8 (ZnT8) for in vivo B-cell imaging and islet-specific therapies
2022Open Access
A cell-surface autoantibody targets zinc transporter-8 (ZnT8) for in vivo B-cell imaging and islet-specific therapies
2022Open Access
Abstract 526: Novel mechanisms of Neuropilin-1 inhibition result in improved tumor growth inhibition <i>in vivo</i>
Cancer Research·2021
Novel autoantibodies to the β-cell surface epitopes of ZnT8 in patients progressing to type-1 diabetes
Journal of Autoimmunity·2021· 20 citedOpen Access
683 A novel mechanism of neuropilin-1 inhibition results in improved tumor growth inhibition in vivo
Regular and Young Investigator Award Abstracts·2020· 2 citedOpen Access
Novel Autoantibodies to the β-Cell Surface Epitopes of ZnT8 in Patients Progressing to Type-1 Diabetes
SSRN Electronic Journal·2020Open Access
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
Journal of Biological Chemistry·2019· 33 citedOpen Access
Water molecules mediate zinc mobility in the bacterial zinc diffusion channel ZIPB
Journal of Biological Chemistry·2019· 20 citedOpen Access
162-OR: Identification of Autoantibodies to ZnT8 Extracellular Epitope(s) in Patients with T1D
Diabetes·2019
Genetic, Functional, and Immunological Study of ZnT8 in Diabetes
International Journal of Endocrinology·2019· 27 citedOpen Access
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8
Journal of Biological Chemistry·2018· 13 citedOpen Access
A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells
Journal of Biological Chemistry·2017· 18 citedOpen Access
Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform
Proceedings of the National Academy of Sciences·2017· 32 citedOpen Access
Coupling of Insulin Secretion and Display of a Granule-resident Zinc Transporter ZnT8 on the Surface of Pancreatic Beta Cells
Journal of Biological Chemistry·2017· 40 citedOpen Access
Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes
Journal of Biological Chemistry·2016· 81 citedOpen Access
The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation
Biochemical Journal·2016· 24 citedOpen Access
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Frequent Co-authors

Dax Fu(14), Liping Yu(5), Qiong Huang(4), Huilin Li(4), Janet M. Wenzlau(3), Devi Kasinathan(3), Maki Nakayama(3), Hua Li(3), G. William Wong(3), Maria L. Golson(3), Jan Pinkas(3), Tejinderjit Athwal(2), Kenneth G. C. Smith(2), Fiona Campbell(2), Robert Sutton(2), John P. Neoptolemos(2), Nikolina Vlatković(2), Yong Gu(2), Xiaofan Jia(2), Huilin Li(2)