John J. Usher

Bristol-Myers Squibb (United States) — United States

Medicine · Health Sciences

13h-index440citations25works0.02yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(12), Chemical Synthesis and Analysis(6), Antibiotic Resistance in Bacteria(5), Antimicrobial Resistance in Staphylococcus(4), Carbohydrate Chemistry and Synthesis(4)

Publications25 total

Purification and characterization of a cephalosporin esterase from Rhodosporidium toruloides
Applied and Environmental Microbiology·1997· 26 citedOpen Access
Purification and Characterization of an Extracellular Alkaline Phosphatase from<i>Penicillium Chrysogenum</i>
Preparative Biochemistry & Biotechnology·1996· 13 cited
Determination of the rate-limiting step(s) in the biosynthetic pathways leading to penicillin and cephalosporin
Journal of Industrial Microbiology & Biotechnology·1992· 11 citedOpen Access
Development of the cephalosporin C fermentation taking into account the instability of cephalosporin C
Biotechnology Letters·1988· 14 cited
Determination by high-performance liquid chromatography of some compounds involved in the biosynthesis of penicillin and cephalosporin
Analytical Biochemistry·1985· 24 cited
ChemInform Abstract: THE SYNTHESIS AND REACTIONS OF A MONOCYCLIC β‐LACTAM TRIPEPTIDE, 1‐((1R)‐CARBOXY‐2‐METHYLPROPYL)‐(3R)‐((5S)‐5‐AMINO‐5‐CARBOXYPENTANAMIDO)‐(4R)‐MERCAPTOAZETIDIN‐2‐ONE, A PUTATIVE INTERMEDIATE IN PENICILLIN BIOSYNTHESIS
Chemischer Informationsdienst·1984
The synthesis and reactions of a monocyclic β-lactam tripeptide, 1-[(1R)-carboxy-2-methylpropyl]- (3R -[(5S-5-amino- 5-carboxypentanamido]-(4R)-mercaptoazetidin-2-one, a putative intermediate in penicillin biosynthesis
Tetrahedron·1984· 11 cited
Penicillin biosynthesis: active site mapping with aminoadipoylcysteinylvaline variants
Journal of the Chemical Society Chemical Communications·1984· 21 cited
ChemInform Abstract: CONVERSION OF 3‐EXOMETHYLENE CEPHALOSPORIN C INTO DEACETYL CEPHALOSPORIN C IN A CELL‐FREE EXTRACT FROM CEPHALOSPORIUM ACREMONIUM (CW‐19)
Chemischer Informationsdienst·1983
Conversion of 3-exomethylene cephalosporin C into deacetyl cephalosporin C in a cell-free extract from Cephalosporium acremonium(CW-19)
Journal of the Chemical Society Chemical Communications·1983· 4 cited
Penicillin biosynthesis. On the stereochemistry of carbon–sulphur bond formation with modified substrates
Journal of the Chemical Society Chemical Communications·1983· 16 cited
Penicillin biosynthesis. Dual pathways from a modified substrate
Journal of the Chemical Society Chemical Communications·1983· 25 cited
ChemInform Abstract: CELL‐FREE BIOSYNTHESIS OF PENICILLINS. CONVERSION OF PEPTIDES INTO NEW β‐LACTAM ANTIBIOTICS
Chemischer Informationsdienst·1982
Cell-free biosynthesis of penicillins. Conversion of peptides into new .beta.-lactam antibiotics
Journal of the American Chemical Society·1981· 38 cited
ChemInform Abstract: SYNTHESIS OF Δ‐(L‐α‐AMINOADIPOYL)‐L‐CYSTEINYL‐D‐VALINE AND SOME CARBON‐13 AND NITROGEN‐15 LABELED ISOTOPOMERS
Chemischer Informationsdienst·1981
Direct<sup>1</sup>H n.m.r. observation of the cell-free conversion of δ-(<scp>L</scp>-α-aminoadipyl)-<scp>L</scp>-cysteinyl-<scp>D</scp>-valine and δ-(<scp>L</scp>-α-aminoadipyl)-<scp>L</scp>-cysteinyl-<scp>D</scp>-(–)-isoleucine into penicillins
Journal of the Chemical Society Chemical Communications·1981· 14 cited
Synthesis of δ-(<scp>L</scp>-α-aminoadipoyl)-<scp>L</scp>-cysteinyl-<scp>D</scp>-valine and some carbon-13 and nitrogen-15 labelled isotopomers
Journal of the Chemical Society Perkin Transactions 1·1981· 29 cited
Penicillin biosynthesis: conversion of deuteriated (<scp>L</scp>-α-amino-δ-adipyl)-<scp>L</scp>-cysteinyl-<scp>D</scp>-valine into isopenicillin N by a cell-free extract of Cephalosporium acremonium
Journal of the Chemical Society Chemical Communications·1981· 8 cited
On the possible role of the 3-methylene isomer of deacetoxycephalosporin C in the biosynthesis of cephalosporins
Journal of the Chemical Society Chemical Communications·1981· 3 cited
ChemInform Abstract: PREPARATION OF THE FOUR ISOMERS OF 4‐HYDROXYVALINE AND THE CORRESPONDING LACTONES
Chemischer Informationsdienst·1980
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Frequent Co-authors

Jack E. Baldwin(14), Edward P. Abraham(7), Robert L. White(7), Robert M. Adlington(6), E. P. Abraham(5), Gamini S. Jayatilake(5), Bulbul Chakravarti(5), Leslie D. Field(5), Gulam Bahadur(4), Mankil Jung(4), Joyce A. Huddleston(3), Brian L. Johnson(3), John A. Murphy(3), Hong-Hoi Ting(3), Doris W. Hughes(3), Carlos Andrés Vallejo(3), PUSHPA D. SINGH(3), Patricia Fawcett(2), Stephen R. Herchen(2), Terence S. M. Wan(2)