Maxwell D. Cummings

Johnson & Johnson (United States) — United States

Medicine · Health Sciences

36h-index4.9kcitations89works2.02yr avg
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Research Topics

Hepatitis C virus research(17), HIV/AIDS drug development and treatment(13), Computational Drug Discovery Methods(12), Monoclonal and Polyclonal Antibodies Research(10), Hepatitis B Virus Studies(8)

Publications89 total

Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis
Journal of Medicinal Chemistry·2025· 2 cited
Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome
Bioorganic & Medicinal Chemistry Letters·2021· 4 cited
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits
Journal of Pharmacology and Experimental Therapeutics·2020· 26 citedOpen Access
ENTEROPEPTIDASE IN COMPLEX WITH COMPOUND 6
2020
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt
Bioorganic & Medicinal Chemistry Letters·2020· 13 citedOpen Access
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach
Bioorganic & Medicinal Chemistry Letters·2020· 16 citedOpen Access
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease
Bioorganic & Medicinal Chemistry Letters·2019· 14 citedOpen Access
3-Substituted Quinolines as RORγt Inverse Agonists
Bioorganic & Medicinal Chemistry Letters·2019· 10 citedOpen Access
Structure-Based Macrocycle Design in Small-Molecule Drug Discovery and Simple Metrics To Identify Opportunities for Macrocyclization of Small-Molecule Ligands
Journal of Medicinal Chemistry·2019· 119 cited
Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?
ACS Omega·2018· 89 citedOpen Access
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy
Bioorganic & Medicinal Chemistry Letters·2018· 38 citedOpen Access
Identification and biological evaluation of thiazole-based inverse agonists of RORγt
Bioorganic & Medicinal Chemistry Letters·2018· 20 citedOpen Access
Protocols for the Design of Kinase‐focused Compound Libraries
Molecular Informatics·2017· 10 cited
6-Substituted quinolines as RORγt inverse agonists
Bioorganic & Medicinal Chemistry Letters·2017· 24 citedOpen Access
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt
Bioorganic & Medicinal Chemistry Letters·2017· 25 citedOpen Access
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation
Proceedings of the National Academy of Sciences·2014· 242 citedOpen Access
Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
Journal of Medicinal Chemistry·2014· 211 cited
Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
Journal of Medicinal Chemistry·2013· 36 cited
Synthetic Macrocycles in Small-Molecule Drug Discovery
Annual reports in medicinal chemistry·2013· 24 cited
Virologic response and characterisation of HCV genotype 2–6 in patients receiving TMC435 monotherapy (study TMC435-C202)
Journal of Hepatology·2012· 87 cited
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Frequent Co-authors

Pierre Raboisson(17), Tianbao Lu(10), Sandrine Vendeville(9), Leen Vijgen(8), Jan Martin Berke(8), Gregory Fanning(8), Origène Nyanguile(8), Raul R. Calvo(7), Jennifer Lattanze(7), Tse‐I Lin(7), Pascale Dehertogh(7), Kenneth Simmen(7), Kristi Leonard(7), Carsten J. Schubert(6), Daniel J. Parks(6), Holly K. Koblish(6), Shuyuan Zhao(6), John Spurlino(6), Anna C. Maroney(6), Oliver Lenz(6)