Christian Fledelius

Novo Nordisk (Denmark) — Denmark

Medicine · Health Sciences

34h-index5.6kcitations79works20.52yr avg
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Research Topics

Pancreatic function and diabetes(18), Adipose Tissue and Metabolism(17), Diabetes Management and Research(9), Bone health and osteoporosis research(8), Diabetes and associated disorders(8)

Publications78 total

Glucose-sensitive insulin with attenuation of hypoglycaemia
Nature·2024· 41 citedOpen Access
Correction to: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
Diabetologia·2024Open Access
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
Diabetologia·2023· 8 citedOpen Access
Glucose-sensitive insulin with attenuation of hypoglycaemia
2023· 3 citedOpen Access
Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones
Molecular Metabolism·2023· 3 citedOpen Access
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor
Chemical Science·2022· 8 citedOpen Access
Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans
Journal of Medicinal Chemistry·2021· 115 cited
Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD
Journal of Translational Medicine·2021· 9 citedOpen Access
Temporal Development of Dyslipidemia and Nonalcoholic Fatty Liver Disease (NAFLD) in Syrian Hamsters Fed a High-Fat, High-Fructose, High-Cholesterol Diet
Nutrients·2021· 13 citedOpen Access
Additional file 1 of Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD
Figshare·2021Open Access
Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes
Journal of Diabetes Research·2020· 2 citedOpen Access
Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models
Journal of Pharmacological and Toxicological Methods·2019· 27 citedOpen Access
Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs
Diabetes Obesity and Metabolism·2019· 11 citedOpen Access
Author response for "Peripherally Delivered Hepatopreferential Insulin Analog Insulin‐406 Mimics the Hypoglycemia‐sparing Effect of Portal Vein Human Insulin Infusion in Dogs"
2019
Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery
JCI Insight·2019· 56 citedOpen Access
Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague–Dawley rats
Diabetology & Metabolic Syndrome·2018· 90 citedOpen Access
Erratum
Digestion·2017Open Access
Supplementary Material for: Diabetic Phenotype in the Small Intestine of Zucker Diabetic Fatty Rats
Figshare·2016Open Access
Acknowledgement to Referees
Digestion·2016Open Access
Contents Vol. 94, 2016
Digestion·2016
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Frequent Co-authors

Per Qvist(10), Claus Christiansen(9), Erica Nishimura(8), M. Bonde(8), Henning Hvid(6), Christian L. Brand(6), Poul Jacobsen(5), Robert Zimmermann(5), Christian Rosenquist(5), Jesper Damgaard(5), Martina Schweiger(4), Rudolf Zechner(4), Stephan Christgau(4), V. Jensen(4), Erik Max Wulff(4), Jens Lykkesfeldt(4), B.J. Riis(3), Patrick Garnero(3), Paul A. Cloos(3), Thomas J. Alsted(3)