Vinay M. Daryani

St. Jude Children's Research Hospital — United States

Medicine · Health Sciences

17h-index908citations27works0.02yr avg
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Research Topics

Glioma Diagnosis and Treatment(7), Neuroblastoma Research and Treatments(6), Cancer therapeutics and mechanisms(4), Lung Cancer Research Studies(4), Sarcoma Diagnosis and Treatment(3)

Publications27 total

Topotecan clearance based on a single sample and a population pharmacokinetic model: Application to a pediatric high‐risk neuroblastoma clinical trial
Pediatric Blood & Cancer·2023Open Access
<scp>LRRK2</scp> Inhibition by <scp>BIIB122</scp> in Healthy Participants and Patients with Parkinson's Disease
Movement Disorders·2023· 99 citedOpen Access
Interim 49-week results of a phase 1/2 study of intravenous DNL310 (brain-penetrant enzyme replacement therapy) in MPS II
Molecular Genetics and Metabolism·2022· 1 cited
Design and preliminary results of a first-in-human, 24-week study of intravenous DNL310 (brain-penetrant IDS) in MPS II
Molecular Genetics and Metabolism·2021
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Science Translational Medicine·2020· 195 cited
Phase I expansion cohort to evaluate the combination of bevacizumab, sorafenib and low-dose cyclophosphamide in children and young adults with refractory or recurrent solid tumours
European Journal of Cancer·2020· 19 citedOpen Access
Pharmacokinetic basis for dosing high‐dose methotrexate in infants and young children with malignant brain tumours
British Journal of Clinical Pharmacology·2019· 28 citedOpen Access
Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations
Cancer Letters·2018· 33 citedOpen Access
A phase II trial evaluating the feasibility of adding bevacizumab to standard osteosarcoma therapy
International Journal of Cancer·2017· 51 citedOpen Access
Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients
Pediatric Nephrology·2017· 23 citedOpen Access
Determination of methotrexate, 7-hydroxymethotrexate, and 2,4-diamino-<i>N</i><sup>10</sup>-methylpteroic acid by LC–MS/MS in plasma and cerebrospinal fluid and application in a pharmacokinetic analysis of high-dose methotrexate
Journal of Liquid Chromatography & Related Technologies·2016· 25 citedOpen Access
Abstract 2708: Development of an individualized 3D transport model of topotecan for a patient-derived orthotopic xenograft model of pediatric neuroblastoma
Cancer Research·2016
A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study
Journal of Neuro-Oncology·2016· 102 cited
Phase II evaluation of sunitinib in the treatment of recurrent or refractory high‐grade glioma or ependymoma in children: a children's Oncology Group Study ACNS1021
Cancer Medicine·2016· 66 citedOpen Access
Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
Drug Metabolism and Disposition·2016· 18 citedOpen Access
Feasibility of Pegylated Interferon in Children and Young Adults With Resected High‐Risk Melanoma
Pediatric Blood & Cancer·2016· 27 citedOpen Access
Neurocognitive and Patient-Reported Outcomes in Adult Survivors of Childhood Osteosarcoma
JAMA Oncology·2015· 54 citedOpen Access
Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma
Neuro-Oncology·2015· 34 citedOpen Access
Assessing vascular effects of adding bevacizumab to neoadjuvant chemotherapy in osteosarcoma using DCE-MRI
British Journal of Cancer·2015· 31 citedOpen Access
Pharmacokinetic Properties of Anticancer Agents for the Treatment of Central Nervous System Tumors: Update of the Literature
Clinical Pharmacokinetics·2015· 54 citedOpen Access
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Frequent Co-authors

Clinton F. Stewart(21), Amar Gajjar(10), Stacy L. Throm(8), K. Elaine Harstead(7), Megan O. Jacus(6), Yogesh T. Patel(6), Jessica K. Roberts(5), Fariba Navid(4), Jianrong Wu(4), Deborah Ward(4), Arzu Onar‐Thomas(4), David C. Turner(4), Giles Robinson(4), Akhil Bhalla(3), James M. Boyett(3), Matthew D. Troyer(3), M. Beth McCarville(3), Barry L. Shulkin(3), Shenghua Mao(3), Alberto S. Pappo(3)