Blaise M. Costa

Virginia Tech — United States

Neuroscience · Life Sciences

7h-index275citations24works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(15), Receptor Mechanisms and Signaling(6), Memory and Neural Mechanisms(4), Ion channel regulation and function(4), Pharmacological Receptor Mechanisms and Effects(4)

Publications24 total

Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator
Journal of Pharmacology and Experimental Therapeutics·2025
A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease
Journal of Alzheimer s Disease Reports·2025Open Access
Effect of quantified cranial osteopathic manipulation on wild type and transgenic rat models of Alzheimer’s disease
2024Open Access
Preliminary pharmacokinetics and <i>in vivo</i> studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator
2024
An Agonist Concentration Biased NMDA Receptor Modulator Produces Analgesic Activity in Experimental Animals
Journal of Pharmacology and Experimental Therapeutics·2024
<scp>CNS4</scp> causes subtype‐specific changes in agonist efficacy and reversal potential of permeant cations in <scp>NMDA</scp> receptors
Pharmacology Research & Perspectives·2023· 5 citedOpen Access
NMDA Receptor Potentiation and Severe Acute Respiratory Syndrome Treatment
2022Open Access
An agonist concentration biased allosteric modulator potentiates NMDA induced ion influx in neurons
2022Open Access
Cranial manipulation affects cholinergic pathway gene expression in aged rats
Journal of Osteopathic Medicine·2022· 7 citedOpen Access
Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
Neuropharmacology·2021· 29 citedOpen Access
NMDA receptor modulation and severe acute respiratory syndrome treatment
F1000Research·2021· 5 citedOpen Access
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons
Pharmacology Research & Perspectives·2021· 10 citedOpen Access
Cranial Manipulation Affects Cholinergic Pathway Gene Expression in an Animal Model of Age-related Cognitive Decline
2020Open Access
Cranial Manipulation Modulates Cholinergic Pathway Gene Expression in an Animal Model of Age-related Cognitive Decline
2020Open Access
Mechanoceutics Alters Alzheimer’s Disease Phenotypes in Transgenic Rats: A Pilot Study
Journal of Alzheimer s Disease·2020· 5 cited
Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease
Journal of Osteopathic Medicine·2019· 11 citedOpen Access
Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid
European Journal of Medicinal Chemistry·2018· 12 citedOpen Access
Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors
European Journal of Pharmacology·2018· 3 cited
Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity
Frontiers in Pharmacology·2017· 7 citedOpen Access
Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study
Journal of Molecular Graphics and Modelling·2015· 5 cited
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Frequent Co-authors

Bradley G. Klein(9), Hope Tobey(7), Ramu Anandakrishnan(7), Seth Boehringer(6), Mark W. Irvine(5), David E. Jane(5), Daniel T. Monaghan(5), Douglas Bledsoe(5), Nakia Phillip(4), Guangyu Fang(3), Bodo Laube(3), Richard F. Helm(3), Brittney Mehrkens(3), Bryanna Vacca(3), Steven Nguyen(3), Osscar Gonzalez Sandoval(3), Pamela J. VandeVord(3), Richard Eaves(2), Erica S. Burnell(2), Kiran Sapkota(2)