Marcus Graf

Thermo Fisher Scientific (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.7kcitations26works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(12), HIV Research and Treatment(8), Immunotherapy and Immune Responses(5), RNA Research and Splicing(5), RNA Interference and Gene Delivery(5)

Publications25 total

Optimizing a Human Papillomavirus Type 16 L1-Based Chimaeric Gene for Expression in Plants
Frontiers in Bioengineering and Biotechnology·2018· 8 citedOpen Access
Correction: Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression
PLoS ONE·2011· 11 citedOpen Access
Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression
PLoS ONE·2011· 158 citedOpen Access
The GeneOptimizer Algorithm: using a sliding window approach to cope with the vast sequence space in multiparameter DNA sequence optimization
Systems and Synthetic Biology·2010· 203 citedOpen Access
Gene optimization mechanisms: A multi‐gene study reveals a high success rate of full‐length human proteins expressed in <i>Escherichia coli</i>
Protein Science·2010· 106 citedOpen Access
Promiscuous behavior of HPV16E6 specific T cell receptor beta chains hampers functional expression in TCR transgenic T cells, which can be restored in part by genetic modification.
PubMed·2010· 5 citedOpen Access
Promiscuous Behavior of HPV16E6 Specific T Cell Receptor Beta Chains Hampers Functional Expression in TCR Transgenic T Cells, Which Can Be Restored in Part by Genetic Modification
Analytical Cellular Pathology·2010Open Access
Rationales of Gene Design and<i>De Novo</i>Gene Construction
2009· 14 cited
La síntesis de genes para la vacuna contra la Gripe A se apoya en los procesos de la ISO 9001
ISO management systems: Revista internacional de las normas ISO 9000 e ISO 14000·2009
Computer aided multi-parameter gene design: impact of synthetic dnas on protein expression enhancement
BMC Systems Biology·2007· 1 citedOpen Access
Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1IIIB Gag-Pol-Nef proteins of clade B
Vaccine·2006· 92 cited
A quasi-lentiviral green fluorescent protein reporter exhibits nuclear export features of late human immunodeficiency virus type 1 transcripts
Virology·2006· 14 cited
Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells
Clinical Immunology·2006· 10 cited
Overexpression and purification of Pyrococcus abyssi phosphopantetheine adenylyltransferase from an optimized synthetic gene for NMR studies
Protein Expression and Purification·2004· 16 cited
Attenuated poxviruses expressing a synthetic HIV protein stimulate HLA-A2-restricted cytotoxic T-cell responses
Vaccine·2004· 26 cited
Codon-Optimized Genes that Enable Increased Heterologous Expression in Mammalian Cells and Elicit Efficient Immune Responses in Mice after Vaccination of Naked DNA
Humana Press eBooks·2004· 37 cited
HIV-1 gag expression is quantitatively dependent on the ratio of native and optimized codons.
PubMed·2003· 18 cited
Co-influence of transgene expression in mammalian cells. Mutual influence of transgenes on their expression in mammalian cells.
PubMed·2003
Codon usage-mediated inhibition of HIV-1 gag expression in mammalian cells occurs independently of translation.
PubMed·2003· 17 cited
Multiple Effects of Codon Usage Optimization on Expression and Immunogenicity of DNA Candidate Vaccines Encoding the Human Immunodeficiency Virus Type 1 Gag Protein
Journal of Virology·2001· 187 citedOpen Access
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Frequent Co-authors

Ralf Wagner(18), Ludwig Deml(5), Hans Wolf(4), Hans Wolf(4), Alexandra Bojak(3), Asli Bauer(3), Michael A. Liss(3), Anne Spriestersbach(3), Barbara Maertens(3), Kurt Bieler(3), Alexander Kofman(3), Thomas Schoedl(3), Kirsten Scholten(3), Duco Kramer(3), Chris J.L.M. Meijer(3), Erik Hooijberg(3), Josef Köstler(2), David Raab(2), Frank Notka(2), Stephan Fath(2)