Chuck T. Chen

University of Toronto — Canada

Nursing · Health Sciences

23h-index2.1kcitations61works0.92yr avg
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Research Topics

Fatty Acid Research and Health(33), Peroxisome Proliferator-Activated Receptors(20), Eicosanoids and Hypertension Pharmacology(12), Adipose Tissue and Metabolism(9), Lipid metabolism and biosynthesis(6)

Publications61 total

Standardized brain and plasma EV enrichment pipeline validated for Single sample multi-Omic and fatty acids applications in Mouse and Human
2026Open Access
PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis
Nature Communications·2025Open Access
Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High‐Fat Diet
FASEB BioAdvances·2025· 1 citedOpen Access
A comprehensive characterization of the phospholipid and cholesterol composition of the uncinate fasciculus in the human brain: evidence of age-related alterations
2025Open Access
Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study
Journal of Lipid Research·2025Open Access
Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat
EMBO Reports·2025· 2 citedOpen Access
Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice
Pharmacological Research·2025· 1 citedOpen Access
Non-nutritive-Sweetened Beverages Are Similar to Water in SSBs Reduction: Strategies to Oppose Sugars With Non-nutritive Sweeteners or Water (STOP Sugars NOW) Trial
Current Developments in Nutrition·2025Open Access
458. Microdoses of Psilocybin Combined With Eugenol are Absorbed and Induce Unique Cerebellar Gene Expression
Biological Psychiatry·2025
Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis
Theranostics·2025· 2 citedOpen Access
Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation
Journal of Advanced Research·2025· 3 citedOpen Access
Lipid mediators in post-mortem brain samples from patients with Alzheimer's disease: A systematic review
Brain Behavior & Immunity - Health·2024· 2 citedOpen Access
Inverse associations between plasma docosahexaenoic acid and pTau181 in the preclinical stages of Alzheimer’s disease
Brain Behavior and Immunity·2024
Vagal Insulin Signaling Regulates Sympathovagal Balance to Determine Peripheral Metabolic and Inflammatory State
2024Open Access
Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate
Nature Communications·2024· 3 citedOpen Access
Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans
Journal of Lipid Research·2023· 9 citedOpen Access
Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption
Pharmacology & Therapeutics·2023· 13 cited
Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study
Nutrients·2023· 13 citedOpen Access
Oleic acid‐bound <scp>FABP7</scp> drives glioma cell proliferation through regulation of nuclear lipid droplet formation
FEBS Journal·2022· 26 citedOpen Access
Author response for "Oleic acid‐bound &lt;scp&gt;FABP7&lt;/scp&gt; drives glioma cell proliferation through regulation of nuclear lipid droplet formation"
2022
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Frequent Co-authors

Richard P. Bazinet(36), Anthony F. Domenichiello(10), Marc‐Olivier Trépanier(8), Zhongjie Fu(7), Adam H. Metherel(7), Kathryn E. Hopperton(5), Frédéric Calon(4), Alex P. Kitson(4), Ameer Y. Taha(4), Joseph R. Hibbeln(4), Sarah Orr(3), Mojgan Masoodi(3), P. Mark Stavro(3), Ann Hellström(3), Lois E. H. Smith(3), Daniel K. Chen(3), Aidan D Tyrrell(3), Sophie E. Haven(3), Mackenzie E. Smith(3), Andrew McCutcheon(3)