James P. Luyendyk

Mayo Clinic — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

46h-index6.7kcitations178works2.02yr avg
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Research Topics

Drug-Induced Hepatotoxicity and Protection(51), Liver Disease Diagnosis and Treatment(43), Liver Disease and Transplantation(31), Liver physiology and pathology(23), Drug Transport and Resistance Mechanisms(19)

Publications175 total

Role of the Plasminogen Activation System in Liver Injury and Repair: Knowns and Known Unknowns
Arteriosclerosis Thrombosis and Vascular Biology·2025· 1 citedOpen Access
HTRS2025.O6A.2 Targeting Fibrinolysis to Prevent Post-hepatectomy Liver Failure: Clinical and Experimental Evidence Linking Plasminogen to Liver Regeneration
Research and Practice in Thrombosis and Haemostasis·2025Open Access
HTRS2025.O8B.6 Tissue transglutaminase induces a concentration-dependent inhibition of fibrin clot turbidity
Research and Practice in Thrombosis and Haemostasis·2025Open Access
Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in patients with trauma
Blood·2025· 2 citedOpen Access
P19-11 Dose-dependent role of fibrin polymerization in early acetaminophen-induced liver injury
Toxicology Letters·2025
Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice
Archives of Toxicology·2025· 2 cited
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury
Toxicological Sciences·2025· 1 cited
α-Naphthylisothiocyanate
Elsevier eBooks·2025
Inflammation and Hepatotoxicity
Elsevier eBooks·2025
Introduction to the Liver: Functional Anatomy and Response to Toxicants
Elsevier eBooks·2025
Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver
Blood·2025· 4 cited
Factor XIII: driving (cross-)links in hemostasis, thrombosis, and disease
Blood·2025· 9 citedOpen Access
Tranexamic acid's protective effect on post-hepatectomy liver failure: post-hoc HeLiX trial analysis
HPB·2025
A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation
American Journal of Physiology-Cell Physiology·2024· 5 citedOpen Access
Platelets are Protective in Early Abdominal Aortic Aneurysm Formation
2024· 1 citedOpen Access
Hepatocyte-independent PAR1-biased signaling controls liver pathology in experimental obesity
Journal of Thrombosis and Haemostasis·2024· 1 citedOpen Access
FRI-342 Visualisation of intrahepatic activation of coagulation and its contribution to disease progression in mice with acetaminophen-induced acute liver injury
Journal of Hepatology·2024
Fibrinolysis-Mediated Pathways in Acute Liver Injury
Seminars in Thrombosis and Hemostasis·2024· 7 citedOpen Access
Neutrophil-dependent hepatic platelet accumulation and liver injury revealed by acetaminophen dose-response studies
Research and Practice in Thrombosis and Haemostasis·2024· 5 citedOpen Access
Good Cells Go Bad: Immune Dysregulation in the Transition from Acute Liver Injury to Liver Failure After Acetaminophen Overdose
Drug Metabolism and Disposition·2023· 7 citedOpen Access
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Frequent Co-authors

Robert A. Roth(15), Nigel Mackman(12), Patricia E. Ganey(12), Anna K. Kopec(10), Jane F. Maddox(9), Bradley P. Sullivan(8), Matthew J. Flick(6), Karen M. Kassel(5), Bryan L. Copple(5), Nikita Joshi(5), Ossama Tawfik(4), Grace L. Guo(4), A. Phillip Owens(4), Jessica A. Williams(3), Gernot Schabbauer(3), Rafał Pawliński(3), Luping Guo(3), Gavin E. Arteel(3), Bo Kong(3), Silvio Antoniak(3)