Mark L. Behnke

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index2.2kcitations32works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Protein Kinase Regulation and GTPase Signaling(5), Ubiquitin and proteasome pathways(5), Inflammatory mediators and NSAID effects(4), Chemical Synthesis and Analysis(4), Chemical Synthesis and Reactions(4)

Publications32 total

<i>In Vivo</i> Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy
Antimicrobial Agents and Chemotherapy·2018· 25 citedOpen Access
The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis
Antimicrobial Agents and Chemotherapy·2018· 26 citedOpen Access
Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926
Organic Process Research & Development·2016· 9 cited
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents
Breast Cancer Research·2015· 71 citedOpen Access
NBL Pistol Grip Tool for Underwater Training of Astronauts
NASA Technical Reports Server (NASA)·2011
Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
Journal of Medicinal Chemistry·2009· 250 citedOpen Access
Synthesis and activity of quinolinylmethyl P1′ α-sulfone piperidine hydroxamate inhibitors of TACE
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists
Journal of Medicinal Chemistry·2008· 106 cited
Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors
Analytical Biochemistry·2008· 9 cited
Indole Cytosolic Phospholipase A<sub>2</sub>α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1<i>H</i>-indol-3-yl]propyl}benzoic Acid, Efipladib
Journal of Medicinal Chemistry·2008· 88 cited
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
Bioorganic & Medicinal Chemistry·2007· 28 cited
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α<sub>2</sub>α
Journal of Medicinal Chemistry·2007· 79 citedOpen Access
Inhibition of Cytosolic Phospholipase A 2 α: Hit to Lead Optimization
2006· 11 cited
Inhibition of Cytosolic Phospholipase A<sub>2</sub>α: Hit to Lead Optimization
Journal of Medicinal Chemistry·2005· 76 citedOpen Access
ChemInform Abstract: A Novel and Efficient Synthesis of a Highly Active Analogue of clasto‐Lactacystin β‐Lactone.
ChemInform·2000· 14 cited
A Novel and Efficient Synthesis of a Highly Active Analogue of <i>clasto</i>-Lactacystin β-Lactone
Journal of the American Chemical Society·1999· 108 cited
ChemInform Abstract: Potent and Selective Inhibitors of the Proteasome: Dipeptidyl Boronic Acids.
ChemInform·1998· 1 cited
Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
Bioorganic & Medicinal Chemistry Letters·1998· 680 citedOpen Access
ChemInform Abstract: Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action.
ChemInform·1994
Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action
Journal of Medicinal Chemistry·1994· 33 cited
page 1 of 2Next →

Frequent Co-authors

Julian Adams(11), John C. McKew(7), Louis Grenier(6), George Majetich(6), Marina W. H. Shen(6), James D. Clark(6), Janice M. Klunder(5), Megan A. Foley(5), Steve Tam(5), Louis Plamondon(4), Karl D. Hargrave(4), Ada M. Casares(4), David Chapman(4), Katherine L. Lee(4), Paresh Thakker(4), Manjunath Ramarao(4), Frank Lovering(4), Martin Tremblay(3), Lin-Chen Yu(3), Somarajan Nair(3)