Mark W. Murphy

University of Minnesota — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.4kcitations45works0.02yr avg
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Research Topics

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities(18), Sperm and Testicular Function(13), Sexual Differentiation and Disorders(11), Epigenetics and DNA Methylation(8), Cancer Genomics and Diagnostics(5)

Publications45 total

Diminished DNA binding affinity of DMRT1 caused by heterozygous DM domain mutations is a cause of male infertility
Human Molecular Genetics·2025Open Access
Data from Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
2023Open Access
Data from Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
2023Open Access
The GDC Application Programming Interface (API) from Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
2023Open Access
The GDC Application Programming Interface (API) from Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
2023· 1 citedOpen Access
Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif
Journal of Biological Chemistry·2022· 20 citedOpen Access
Genomics of sexual cell fate transdifferentiation in the mouse gonad
G3 Genes Genomes Genetics·2022· 6 citedOpen Access
Structural insights into AT-rich DNA recognition by SALL family proteins
2022Open Access
Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis
PLoS Genetics·2022· 7 citedOpen Access
DMRT1: An Ancient Sexual Regulator Required for Human Gonadogenesis
Sexual Development·2021· 99 citedOpen Access
Author Correction: The NCI Genomic Data Commons
Nature Genetics·2021· 1 citedOpen Access
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
Nucleic Acids Research·2021· 69 citedOpen Access
The NCI Genomic Data Commons
Nature Genetics·2021· 174 cited
Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
Cancer Research·2017· 41 citedOpen Access
In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures
Nucleic Acids Research·2017· 100 citedOpen Access
A Case for Data Commons: Toward Data Science as a Service
Computing in Science & Engineering·2016· 78 citedOpen Access
A Case for Data Commons: Towards Data Science as a Service
arXiv (Cornell University)·2016· 11 citedOpen Access
A Role for DMRT1 in Human Primary Sex-Determination
54th ESPE Meeting (ESPE 2015)·2015
An ancient protein-DNA interaction underlying metazoan sex determination
Nature Structural & Molecular Biology·2015· 123 citedOpen Access
Conserved genomic signature defines fetal sertoli cell fate in mammals
SPIRE - Sciences Po Institutional REpository·2015
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Frequent Co-authors

David Zarkower(24), Vivian J. Bardwell(21), Allison P. Heath(9), Robert L. Grossman(9), Vincent Ferretti(7), Martin L. Ferguson(7), Himanso Sahni(7), Zhining Wang(7), Christine Yu(7), Junjun Zhang(7), Louis M. Staudt(7), Micah D. Gearhart(7), Aaron L. Sarver(6), Pearlly S. Yan(6), David Frankhouser(5), John Curfman(5), Ralf Bundschuh(5), Guido Marcucci(5), Clinton K. Matson(4), Anthony D. Krentz(4)