Louise K. Modis

Mission Therapeutics (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index2.9kcitations26works4.32yr avg
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Research Topics

Sphingolipid Metabolism and Signaling(7), Immune cells in cancer(6), Immune Response and Inflammation(3), Lipid Membrane Structure and Behavior(3), Immune Cell Function and Interaction(3)

Publications26 total

Amx-883, a potent and selective degrader of BRD9 drives differentiation in acute myeloid leukaemia and shows synergistic efficacy in combination with venetoclax In Vivo and prevents the emergence of resistance to venetoclax in vitro.
Blood·2025Open Access
Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9
Nature Communications·2025· 6 citedOpen Access
Efficacy, safety and tolerability of GSK3858279, an anti-CCL17 monoclonal antibody and analgesic, in healthy volunteers and patients with knee osteoarthritis pain: a phase I, randomised, double-blind, placebo-controlled, proof-of-mechanism and proof-of-concept study
Annals of the Rheumatic Diseases·2024· 7 citedOpen Access
Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages
Frontiers in Immunology·2022· 12 citedOpen Access
miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease
The Journal of Experimental Medicine·2022· 28 citedOpen Access
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications·2022· 33 citedOpen Access
Immune-mediated inflammation across disease boundaries: breaking down research silos
Nature Immunology·2021· 29 cited
Sublytic membrane attack complex drives glycolysis and mitochondrial dysfunction with inflammatory consequences in human monocyte-derived macrophages
Research Square (Research Square)·2021Open Access
Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages
PLoS Pathogens·2021· 37 citedOpen Access
CCL17 in Inflammation and Pain
The Journal of Immunology·2020· 39 cited
Epigenetic Regulation of T Cell Memory: Recalling Therapeutic Implications
Trends in Immunology·2019· 63 cited
Malonylation of GAPDH is an inflammatory signal in macrophages
Nature Communications·2019· 195 citedOpen Access
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Nature·2018· 1.7k citedOpen Access
An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Journal of Biological Chemistry·2018· 181 citedOpen Access
Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists
Bioorganic & Medicinal Chemistry Letters·2015Open Access
RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
Journal of Neuroimmunology·2014· 94 cited
Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists
Bioorganic & Medicinal Chemistry Letters·2014· 6 citedOpen Access
CCR1 Plays a Critical Role in Modulating Pain through Hematopoietic and Non-Hematopoietic Cells
PLoS ONE·2014· 18 citedOpen Access
A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo
PLoS ONE·2014· 74 citedOpen Access
No Differences Observed among Multiple Clinical S1P1 Receptor Agonists (Functional Antagonists) in S1P1 Receptor Down-regulation and Degradation
SLAS DISCOVERY·2013· 13 citedOpen Access
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Frequent Co-authors

Martha Triantafilou(5), Kathy Triantafilou(5), Nuruddeen D. Lewis(5), Dimitria E. Stefanopoulos(5), Lori Patnaude(5), Susan Lukas(5), Lee M. Booty(4), Luke O'neill(4), Shawn Anderson(4), Melissa Hill-Drzewi(4), Richard G. Carroll(3), Emma Koppe(3), Joshua C. Horan(3), Josephine Pelletier(3), Daniel Kuzmich(3), Christian Harcken(3), Eugene R. Hickey(3), Sokol Haxhinasto(3), Maryanne L. Brown(3), Gisela Jimenez‐Duran(3)