Stephen F. Traynelis

Emory University — United States

Neuroscience · Life Sciences

85h-index29.6kcitations335works4.82yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(227), Ion channel regulation and function(116), Receptor Mechanisms and Signaling(83), Genetics and Neurodevelopmental Disorders(41), Nicotinic Acetylcholine Receptors Study(27)

Publications335 total

Correction: GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy
Molecular Psychiatry·2026Open Access
Memantine treatment in individuals with <scp>GRIN</scp> gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency
Epilepsia·2026· 1 citedOpen Access
Mechanism of conductance control and neurosteroid binding in NMDA receptors
Nature·2025· 2 cited
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution
2025Open Access
GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy
Molecular Psychiatry·2025Open Access
Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation
The Journal of Physiology·2025Open Access
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution
2025Open Access
Inhibition of GluN2B-containing <i>N</i> -methyl- <scp>D-</scp> aspartate receptors by radiprodil
Brain·2025
Striatal GluN2A gene suppression reduces L-DOPA-induced abnormal involuntary movements in parkinsonian rats
Neuropharmacology·2025· 2 citedOpen Access
The thrombin receptor PAR1 orchestrates changes in lymphatic endothelial cell junction morphology to augment lymphatic drainage during lung injury
Nature Cardiovascular Research·2025· 3 citedOpen Access
Selective enhancement of the interneuron network and gamma‐band power via GluN2C/GluN2D NMDA receptor potentiation
The Journal of Physiology·2025· 3 citedOpen Access
Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the <i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor
Journal of Medicinal Chemistry·2025· 4 cited
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy
Brain·2025· 4 cited
Structural basis for channel gating and blockade in tri-heteromeric GluN1-2B-2D NMDA receptor
Neuron·2025· 11 cited
BPS2025 - Functional characterization of GRIN2B variants using automated patch clamp technology
Biophysical Journal·2025
Ligand distances as key predictors of pathogenicity and function in NMDA receptors
Human Molecular Genetics·2024· 6 citedOpen Access
Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation
2024· 1 citedOpen Access
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor
Molecular Pharmacology·2024· 6 citedOpen Access
Clinical development of the GluN2B-selective NMDA receptor inhibitor NP10679 for the treatment of neurologic deficit after subarachnoid hemorrhage
Journal of Pharmacology and Experimental Therapeutics·2024· 6 cited
β-hydroxybutyrate improves convulsions in mice carrying the <i>GRIN1</i> Y647S/+ pathogenic variant
2024· 4 citedOpen Access
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Frequent Co-authors

Hongjie Yuan(15), Kasper B. Hansen(8), Raymond Dingledine(7), Polina Lyuboslavsky(6), Kevin K. Ogden(5), Tue G. Banke(5), Derek Bowie(4), Stuart Cull-Candy(4), Kevin Erreger(4), David J. A. Wyllie(4), Melissa B. Gingrich(4), Wenjuan Chen(4), Chun Hu(4), C. Justin Lee(4), Lonnie P. Wollmuth(3), Chris J. McBain(3), Frank S. Menniti(3), Katie M. Vance(3), Chian‐Ming Low(3), Riley E. Perszyk(3)