Brian L. Mark

Children's Hospital Research Institute of Manitoba — Canada

Chemistry · Physical Sciences

36h-index3.7kcitations124works5.02yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(32), Lysosomal Storage Disorders Research(28), Antibiotic Resistance in Bacteria(18), Glycosylation and Glycoproteins Research(17), Enzyme Production and Characterization(16)

Publications124 total

Generation of mice with combined <i>Hexa</i> Gly269Ser KI or KO and <i>Neu3</i> KO alleles to create new models of GM2 gangliosidoses
Biology Open·2025· 1 citedOpen Access
Inhibiting Infectious Bronchitis Virus PLpro Using Ubiquitin Variants
International Journal of Molecular Sciences·2025Open Access
Suppressing Tymovirus replication in plants using a variant of ubiquitin
PLoS Pathogens·2025· 4 citedOpen Access
Viral deubiquitinating proteases and the promising strategies of their inhibition
Virus Research·2024· 6 citedOpen Access
Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo
PLoS Pathogens·2024· 19 citedOpen Access
Evaluation of the effects of HexM and its mannose-6-hyper-phosphorylated form (PhosHexM) in reducing GM2 ganglioside storage in a Tay-Sachs disease mouse model
Molecular Genetics and Metabolism·2024
Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
PLoS Pathogens·2023· 5 citedOpen Access
Biochemical Insights into Imipenem Collateral Susceptibility Driven by <i>ampC</i> Mutations Conferring Ceftolozane/Tazobactam Resistance in Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy·2023· 12 citedOpen Access
Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site
PLoS Pathogens·2022· 36 citedOpen Access
Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses
BBA Advances·2021· 2 citedOpen Access
The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase
Journal of Biological Chemistry·2021· 8 citedOpen Access
Maize rayado fino virus protease
2021
Maize rayado fino virus protease in complex with Ubiquitin
2021
Characterization of the sorbitol dehydrogenase SmoS from <i>Sinorhizobium meliloti</i> 1021
Acta Crystallographica Section D Structural Biology·2021· 6 cited
Determining the Electronic Structure Paramagnetic Intermediates in Membrane Proteins: A High-Resolution 2D 1H Hyperfine Sublevel Correlation Study of the Redox-Active Tyrosines of Photosystem II
Biophysical Journal·2021Open Access
Understanding the Mechanism of Proton-Coupled Electron Transfer in the Bioinspired Artificial Photosynthetic Mimic, Benzimidazole Phenol Porphyrin
Biophysical Journal·2021Open Access
Letter to the Editor
Molecular Therapy·2020Open Access
Frontrunners in the race to develop a SARS-CoV-2 vaccine
Canadian Journal of Microbiology·2020· 14 citedOpen Access
Molecular characterization of the RNA-protein complex directing −2/−1 programmed ribosomal frameshifting during arterivirus replicase expression
Journal of Biological Chemistry·2020· 15 citedOpen Access
Determining the Electronic Structure of Paramagnetic Intermediates in membrane proteins: A high-resolution 2D 1H hyperfine sublevel correlation study of the redox-active tyrosines of photosystem II
Biochimica et Biophysica Acta (BBA) - Biomembranes·2020· 4 citedOpen Access
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Frequent Co-authors

David J. Vocadlo(16), Michael N.G. James(8), Ben A. Bailey-Elkin(8), Keith A. Stubbs(8), Eric J. Snijder(7), Marjolein Kikkert(7), Stephen G. Withers(6), Don J. Mahuran(5), J.P. Bacik(5), Antonio Oliver(5), Barbara L. Triggs‐Raine(4), Robert C. M. Knaap(4), Puck B. van Kasteren(4), Grishma Vadlamani(4), Thomas M. Reeve(4), Spencer Knapp(3), M.M. Cherney(3), Terrence W. James(3), Mazdak Khajehpour(3), M.D. Balcewich(3)