Alexander Strom

University of Minnesota — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index342citations22works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

RNA and protein synthesis mechanisms(9), Protein Structure and Dynamics(6), Biochemical and Molecular Research(5), Bacterial Genetics and Biotechnology(3), HIV/AIDS drug development and treatment(3)

Publications22 total

Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides
Biochemistry·2022· 2 citedOpen Access
Characterizing the binding dynamics of cyclic-G/AMP synthase (cGAS) to nucleosomes with single-molecule resolution
Biophysical Journal·2022
“Switching On” Enzyme Substrate Specificity Analysis with a Fluorescent Competitive Inhibitor
Biochemistry·2021
Histidine triad nucleotide‐binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A
FEBS Letters·2020· 17 citedOpen Access
Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice
ACS Chemical Neuroscience·2019· 16 cited
Investigating the Kinetic Effects of the Allosteric Interaction Between Newly‐Discovered Dynamic Hydrogen‐Bonded Residues and the HINT1 Active Site
The FASEB Journal·2019
Kinetic and Structural Comparison of HINT Enzymes: The Role of Distant Dynamics on Catalysis
Biophysical Journal·2019Open Access
Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia
Journal of Molecular Biology·2018· 11 citedOpen Access
A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides
Molecular Pharmaceutics·2017· 20 cited
Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain
Biochemical and Biophysical Research Communications·2017· 8 cited
A Comparative Study of All-atom Molecular Dynamics Simulation and Coarse-grained Normal Mode Analysis in Identifying Pre-existing Residue Interaction Networks that Promote Coupled-Domain Dynamics in Escherichia coli Methionyl-tRNA Synthetase
American Journal of Undergraduate Research·2017· 2 citedOpen Access
A structure-based guide to building hHint-1 activated nucleotide prodrugs
Acta Crystallographica Section A Foundations and Advances·2017Open Access
Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1
ACS Medicinal Chemistry Letters·2016· 15 citedOpen Access
Comparison of intrinsic dynamics of cytochrome p450 proteins using normal mode analysis
Protein Science·2015· 13 citedOpen Access
Probing the global and local dynamics of aminoacyl-tRNA synthetases using all-atom and coarse-grained simulations
Journal of Molecular Modeling·2014· 17 citedOpen Access
Principal Component Analysis to Explore Transition Pathway of the Conformational Change in E. Faecalis Prolyl-tRNA Synthetase upon Substrate Binding
Minds at UW (University of Wisconsin)·2014Open Access
Comparison of the Intrinsic Dynamics of Aminoacyl-tRNA Synthetases
The Protein Journal·2014· 14 cited
Multiple Pathways Promote Dynamical Coupling between Catalytic Domains in <i>Escherichia coli</i> Prolyl-tRNA Synthetase
Biochemistry·2013· 17 citedOpen Access
Computational and Experimental Studies to Unravel the Role of Editing Domain of Bacterial Prolyl-tRNA Synthetases in Amino Acid Activation
Minds at UW (University of Wisconsin)·2012Open Access
Comparison of Coarse-Grained and Atomistic-Level Simulations for Aminoacyl-tRNA Synthetases
Minds at UW (University of Wisconsin)·2012Open Access
page 1 of 2Next →

Frequent Co-authors

Carston R. Wagner(10), Rachit Shah(7), Sanchita Hati(6), B.C. Finzel(6), Sudeep Bhattacharyya(5), K.M. Maize(5), Stephanie N. Tadayon(4), Samuel C. Fehling(4), James M. Johnson(3), Brent P. Lehman(3), Brianne Sanford(2), Karin Musier‐Forsyth(2), Sidath C. Kumarapperuma(2), Andrew Zhou(2), Arrianna Zirbes(2), Yer Yang(2), Catharina Jürgens(1), Dennis Wegener(1), Stefan Hettwer(1), Matthias Wilmanns(1)