Francis G. Spinale

University of South Carolina — United States

Medicine · Health Sciences

85h-index24.7kcitations597works0.72yr avg
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Research Topics

Cardiac Fibrosis and Remodeling(192), Cardiovascular Function and Risk Factors(107), Peptidase Inhibition and Analysis(94), Protease and Inhibitor Mechanisms(88), Signaling Pathways in Disease(67)

Publications594 total

Abstract 4362971: Localized hydrogel delivery of a small molecule inhibitor of fibroblast activation protein alters the trajectory of post-myocardial infarction remodeling
Circulation·2025
Abstract 4365727: The role of fibroblast activation protein on left ventricular geometry, growth and extracellular matrix remodeling with pressure overload
Circulation·2025
Abstract 4342582: Modifying the progression of heart failure with preserved ejection fraction (HFpEF) in pigs by a regular exercise regimen; Effects on LV function and structure
Circulation·2025
Abstract 4343931: The Inflammasome and Fibroblast Transdifferentiation and Activation in Heart Failure with Reduced Ejection Fraction
Circulation·2025
Abstract 4363930: Higher fibroblast activation protein identifies improved myocardial plasticity and positive response to cardiac resynchronization therapy
Circulation·2025
Abstract 4343925: The Inflammasome and Fibroblast Activation Protein in Heart Failure with Reduced Ejection Fraction
Circulation·2025
Abstract 4343917: Myocardial stiffness properties are improved in heart failure with preserved ejection fraction (HFpEF) in pigs by a regular exercise regime
Circulation·2025
Abstract 4373120: Assessment of Adverse Left Ventricular Remodeling Following Ischemia Reperfusion Injury with SPECT Imaging Agent Targeting Fibroblast Activation Protein
Circulation·2025
Abstract 4363991: The role of fibroblast activation protein on left ventricular growth and matrix signaling as a function of age
Circulation·2025
Intramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial Infarction
Circulation Cardiovascular Imaging·2025· 2 cited
Abstract TAC236: NLPR3 inflammasome inhibitor attenuates autoimmune mediated hypertension in female mice
Hypertension·2025
Remodeling-mediated changes in left ventricular mechanics under settings of chronic pressure overload and exercise
2025Open Access
Sex-specific effects of chronic unpredictable stress on mitochondrial function in the HPA axis in mice
2025· 2 citedOpen Access
Towards the Integration of an Anti-Contractile Compound Within Drug-Coated Balloon Therapy
Cardiovascular Engineering and Technology·2025Open Access
Diffuse Myocardial Fibrosis
JACC Basic to Translational Science·2025· 1 citedOpen Access
Using Foundation Models as Pseudo-Label Generators for Pre-Clinical 4D Cardiac CT Segmentation
arXiv (Cornell University)·2025Open Access
Gestational witness stress impacts postpartum brain, behavior, and cardiovascular health in Wistar female rats
Physiology·2025· 1 cited
The effects of chronic unpredictable stress on renal sex steroids and renal mitochondrial function in C57Bl/6 females
Physiology·2025
Engineering nanoparticles that target fibroblast activation protein in cardiac fibrosis
2025· 1 citedOpen Access
Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling
JACC Basic to Translational Science·2025· 3 citedOpen Access
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Frequent Co-authors

Michael R. Zile(13), Mytsi L. Coker(9), Rupak Mukherjee(8), Robert E. Stroud(7), Leslie L. Clark(5), John S. Ikonomidis(5), Robert C. Gorman(4), Catherine McClure(4), Kathryn B. Dowdy(4), Anne M. Deschamps(4), Jeffrey A. Jones(4), Merry L. Lindsey(4), Douglas L. Mann(3), Takuma Etoh(3), James L. Zellner(3), Chadwick V. Thomas(3), Carson S. Webb(3), D. Dirk Bonnema(3), Mark J. Clair(3), G. Patricia Escobar(3)