Jennifer Lachey

Acceleron Pharma (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index2.3kcitations46works2.22yr avg
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Research Topics

Muscle Physiology and Disorders(24), Adipose Tissue and Metabolism(7), Regulation of Appetite and Obesity(5), TGF-β signaling in diseases(5), GDF15 and Related Biomarkers(5)

Publications45 total

Compound KTI-2338 Inhibits ACVR1 Receptor Signaling in Fibrodysplasia Ossificans Progressiva
Pharmaceutics·2025Open Access
ACE-031, a Soluble Activin Type IIB Receptor, Increases Muscle Mass and Strength in the Common Marmoset (Callithrix jacchus)
2025Open Access
652PRKER-065 improved the therapeutic response to phosphorodiamidate morpholino oligomers (PMO) in a Duchenne muscular dystrophy mouse model
Neuromuscular Disorders·2025
Endothelial ActRIIA inhibition protects the cardiac microvasculature in severe viral respiratory infection
2025Open Access
A Recombinant Antibody Against <scp>ALK2</scp> Promotes Tissue Iron Redistribution and Contributes to Anemia Resolution in a Mouse Model of Anemia of Inflammation
American Journal of Hematology·2025· 5 citedOpen Access
Elritercept, a modified activin receptor IIA ligand trap, increased erythropoiesis and thrombopoiesis in a phase 1 trial
Blood Advances·2024· 8 citedOpen Access
P33 RKER-065 ameliorated muscle and bone loss in a progressive murine model of Duchenne muscular dystrophy
Neuromuscular Disorders·2023· 2 cited
P34 RKER-065, a novel ActRII ligand trap, counteracted the negative impact of glucocorticoid treatment on bone and muscle
Neuromuscular Disorders·2023
P64 An activin type II receptor ligand trap prevented loss of cortical bone strength and cancellous bone mass in a mouse model of severe disuse osteopenia
Neuromuscular Disorders·2023
Abstract P321: &lt;RKER-012, A Novel Activin Receptor Type Ilb (actrllb) Ligand Trap, Inhibited Mediators Of Dysregulated Vascular Remodeling In Pulmonary Arterial Endothelial And Smooth Muscle Cells&gt;
Hypertension·2023
Abstract 11565: Improvement in Cardiopulmonary Function in a Rat Model of Pulmonary Arterial Hypertension Observed With RKER-012, a Novel Activin Receptor Type II Ligand Trap, was Associated With Reduced Markers of Inflammation and Fibrosis in the Right Ventricle
Circulation·2022
Abstract 11209: KER-012, a Novel Modified ActrII Ligand Trap, Attenuated Cardiac Pathology in a Pulmonary Arterial Banding Model of Right Ventricle Overload
Circulation·2021
Selective Inhibition of ALK2 Signaling Suppresses Serum Hepcidin and Increases Serum Iron
Blood·2020
P.127KER-050, a novel muscle anabolic, functions as a ligand trap that binds myo-catabolic TGFβ ligands and has reduced binding affinity for BMP9, a critical vascular remodeling ligand
Neuromuscular Disorders·2019
Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle
Journal of Pharmacology and Experimental Therapeutics·2018· 26 citedOpen Access
Inhibition of the Activin Receptor Type-2B Pathway Restores Regenerative Capacity in Satellite Cell-Depleted Skeletal Muscle
Frontiers in Physiology·2018· 11 citedOpen Access
Electrical impedance myography for the <i>in vivo</i> and <i>ex vivo</i> assessment of muscular dystrophy (<i>mdx</i>) mouse muscle
Muscle & Nerve·2014· 60 citedOpen Access
Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice
American Journal Of Pathology·2014· 34 citedOpen Access
A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling
Endocrinology·2012· 106 citedOpen Access
ACE-031 (Soluble Activin Receptor Type IIB-IgG1) Increases Muscle Mass by Inhibiting Myostatin and Other Negative Regulators of Muscle: Non-Clinical and Clinical Studies
2011
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Frequent Co-authors

Jasbir Seehra(23), Abigail Pullen(8), R. Scott Pearsall(7), Emidio E. Pistilli(7), Sasha Bogdanovich(6), Tejvir S. Khurana(5), J. Seehra(5), Randy J. Seeley(4), Ravindra Kumar(4), Dianne Sako(4), Jeffrey A. Ucran(4), Joel K. Elmquist(3), Samuel M. Cadena(3), Kathryn Underwood(3), Marcus D. Goncalves(3), Rexford S. Ahima(3), Alan Koncarevic(3), Asya V. Grinberg(3), Katia Liharska(3), Evan Lema(3)