Tuomas P. J. Knowles

University of Cambridge — United Kingdom

Medicine · Health Sciences

102h-index45.5kcitations721works7.42yr avg
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Research Topics

Alzheimer's disease research and treatments(240), Protein Structure and Dynamics(173), Supramolecular Self-Assembly in Materials(108), Prion Diseases and Protein Misfolding(93), RNA Research and Splicing(75)

Publications721 total

Cell-Level Model to Predict the Spatiotemporal Dynamics of Neurodegenerative Disease
PRX Life·2026Open Access
<i>In vitro</i> liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
2025Open Access
Mapping high resolution, multidimensional phase diagrams of physiological protein condensates
2025Open Access
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
ACS Nano·2025Open Access
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
Nature Communications·2025· 1 citedOpen Access
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning
ACS Nano·2025Open Access
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
Advanced Science·2025· 1 citedOpen Access
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
Communications Chemistry·2025Open Access
Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates
ACS Omega·2025Open Access
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
2025Open Access
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
2025
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
2025· 3 citedOpen Access
Dissecting the molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation
2025· 1 citedOpen Access
Direct, high-throughput linking of single-cell imaging and gene expression
2025Open Access
Transcript Identification Using Arrayed Hydrogels With TrapFISH (Adv. Mater. Technol. 18/2025)
Advanced Materials Technologies·2025Open Access
Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior
JACS Au·2025· 4 citedOpen Access
The role of N-terminal acetylation on biomolecular condensation
2025Open Access
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
2025Open Access
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
2025Open Access
Current practices in the study of biomolecular condensates: a community comment
Nature Communications·2025· 30 citedOpen Access
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Frequent Co-authors

Christopher M. Dobson(34), Michele Vendruscolo(26), Sara Linse(14), Samuel I. A. Cohen(13), Georg Meisl(10), Paolo Arosio(10), David Klenerman(7), Thomas C. T. Michaels(7), Alexander K. Buell(7), Mark E. Welland(6), Céline Galvagnion(6), Francesco Simone Ruggeri(4), Nunilo Cremades(4), Francesco A. Aprile(4), Johnny Habchi(4), Sean Chia(4), Daniel E. Otzen(3), Christopher A. Waudby(3), Glyn L. Devlin(3), Seema Qamar(3)