Aileen Rubio

Medicine · Health Sciences

22h-index1.9kcitations41works3.52yr avg
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Research Topics

Antimicrobial Resistance in Staphylococcus(13), Bacterial biofilms and quorum sensing(11), Antibiotic Resistance in Bacteria(8), Bacterial Genetics and Biotechnology(7), RNA and protein synthesis mechanisms(6)

Publications41 total

FRI-230 Naïve C57BL/6 mice immunized with CLB-405 and CLB-505 combined with a saponin-based adjuvant TQL-1055 exhibit a dose-dependent humoral and cellular immune
Journal of Hepatology·2025
SAT-339 Sequential administration of siRNA with an mRNA encoding clearance profile associated variants of HBsAg exhibits significant antiviral activity in AAV/HBV mouse model
Journal of Hepatology·2024
TOP-353 An mRNA vaccine exhibits anti-viral activity in mouse model of persistent hepatitis B infection
Journal of Hepatology·2024
Efficacy of SPR720 in murine models of non-tuberculous mycobacterial pulmonary infection
Journal of Antimicrobial Chemotherapy·2024· 14 citedOpen Access
Therapeutic vaccine candidate CLB-3000 (CLB-405 and CLB-505 adjuvanted with Alhydrogel): a Good Laboratory Practice (GLP)-compliant 15-week intramuscular toxicity study in rabbits with a 4-week recovery
Journal of Hepatology·2023
A monoclonal antibody 4G2 exhibits anti-viral activity in mouse models of chronic hepatitis B
Journal of Hepatology·2023· 1 cited
<i>In vitro</i> activity and <i>in vivo</i> efficacy against non-tuberculous mycobacteria of SPR719, the active moiety of the novel oral benzimidazole prodrug SPR720
2022· 1 citedOpen Access
Therapeutic vaccination with CLB-3000 in a mouse model of chronic hepatitis B induces anti-HBs responses associated with functional cure
Journal of Hepatology·2022· 1 cited
<i>In Vitro</i> and <i>In Vivo</i> Characterization of Tebipenem, an Oral Carbapenem
Antimicrobial Agents and Chemotherapy·2020· 30 citedOpen Access
Evaluation of Antimicrobial Effects of a New Polymyxin Molecule (SPR741) When Tested in Combination with a Series of β-Lactam Agents Against a Challenge Set of Gram-Negative Pathogens
Microbial Drug Resistance·2019· 12 cited
Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane
ACS Infectious Diseases·2019· 104 citedOpen Access
Effects of Acute Lung Inflammation on Zinc Pharmacokinetics
2019
Antimicrobial Activity Evaluation of Tebipenem (SPR859), an Orally Available Carbapenem, against a Global Set of Enterobacteriaceae Isolates, Including a Challenge Set of Organisms
Antimicrobial Agents and Chemotherapy·2019· 38 citedOpen Access
<i>In Vitro</i> Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria
Antimicrobial Agents and Chemotherapy·2019· 20 citedOpen Access
Shared Platform for Antibiotic Research and Knowledge: A Collaborative Tool to SPARK Antibiotic Discovery
ACS Infectious Diseases·2018· 16 citedOpen Access
<i>In Vitro</i> Susceptibility Testing of a Novel Benzimidazole, SPR719, against Nontuberculous Mycobacteria
Antimicrobial Agents and Chemotherapy·2018· 55 citedOpen Access
Characterization of SPR994, an Orally Available Carbapenem, with Activity Comparable to Intravenously Administered Carbapenems
ACS Infectious Diseases·2018· 8 cited
Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC–MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition
Journal of Pharmaceutical and Biomedical Analysis·2017· 14 cited
Perception of health-related quality of life using the EURO-QOL in older adults in Bogotá, Colombia
European Geriatric Medicine·2016· 8 cited
Dysregulation of<i>mprF</i>and<i>dltABCD</i>expression among daptomycin-non-susceptible MRSA clinical isolates
Journal of Antimicrobial Chemotherapy·2016· 53 citedOpen Access
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Frequent Co-authors

Nagendra N. Mishra(6), Arnold S. Bayer(6), Nicole Cotroneo(6), Michael J. Pucci(5), Bharat C. Dixit(5), Soo‐Jin Yang(4), Jared Silverman(4), Kit Pogliano(4), Aditi Deshpande(4), Cynthia C. Nast(3), Xin Jiang(3), Anton Y. Peleg(2), David R. Cameron(2), Robert C. Moellering(2), George M. Eliopoulos(2), Michael R. Yeaman(2), Liang Chen(2), Barry N. Kreiswirth(2), Troy Lister(2), Mary Conrad(2)