Jason Ear

California State Polytechnic University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.3kcitations47works3.32yr avg
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Research Topics

Cancer-related gene regulation(11), Protein Kinase Regulation and GTPase Signaling(9), Wnt/β-catenin signaling in development and cancer(8), RNA modifications and cancer(7), Microtubule and mitosis dynamics(5)

Publications47 total

Daple-FLT3 (CCDC88C-FLT3) gene fusion requires the coiled-coil domain for maximal activation and pericentrosomal localization
2025Open Access
A living organoid biobank of patients with Crohn’s disease reveals molecular subtypes for personalized therapeutics
Cell Reports Medicine·2024· 15 citedOpen Access
Abstract 1665: Investigating Daple-FLT3 gene fusion in leukemia cells and its response to kinase inhibitors
Cancer Research·2024
Abstract 1681: Characterizing signaling and localization of Daple-FLT3 gene fusion in leukemia cells
Cancer Research·2024
Abstract 1679: Understanding the mechanism of Daple-PDGFRB gene fusion in leukemia
Cancer Research·2024
Complement receptor 3 is required for maximum in vitro trogocytic killing of the parasite <i>Trichomonas vaginalis</i> by human neutrophil‐like cells
Parasite Immunology·2024· 5 citedOpen Access
A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics
2023· 4 citedOpen Access
Regulation of DNA damage response by trimeric G-proteins
iScience·2023· 9 citedOpen Access
A Prospectively Created Living Organoid Biobank of Crohn’s Disease Patients Enables Integrative Therapeutics
The Journal of Immunology·2022
Regulation of DNA damage response by trimeric G-protein Signaling
2021· 1 citedOpen Access
E-cigarettes compromise the gut barrier and trigger inflammation
iScience·2021· 78 citedOpen Access
A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding
Journal of Biological Chemistry·2021· 9 citedOpen Access
Evolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates
2020Open Access
E-cigarettes compromise the gut barrier and trigger gut inflammation
2020· 4 citedOpen Access
Correction: DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi.
Journal of Biological Chemistry·2020Open Access
Tyrosine‐based Signals Converge on Daple&amp;[bull]PARD3 Complex to Fine‐tune Polarized Planar Cell Migration
The FASEB Journal·2020
Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions
iScience·2020· 10 citedOpen Access
DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi
Journal of Biological Chemistry·2020· 16 citedOpen Access
Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors
Scientific Reports·2019· 19 citedOpen Access
Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma
Scientific Reports·2018· 10 citedOpen Access
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Frequent Co-authors

Pradipta Ghosh(32), Mikel Garcia‐Marcos(11), Nicolas Aznar(11), Debashis Sahoo(9), Ying Dunkel(9), Irina Kufareva(8), Majid Ghassemian(7), Soumita Das(7), Nina Sun(7), Marilyn G. Farquhar(6), Navin Rajapakse(6), Shuo Lin(5), Jasper Lee(5), Ayden G. Fonseca(5), Ibrahim M. Sayed(5), Inmaculada López-Sánchez(5), Stella‐Rita Ibeawuchi(4), Rama F. Pranadinata(4), Julie Choi(4), Amer Ali Abd El‐Hafeez(4)