Robert Zaczek

NeurOp (United States) — United States

Neuroscience · Life Sciences

41h-index5.7kcitations134works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Neuroscience and Neuropharmacology Research(64), Cholinesterase and Neurodegenerative Diseases(30), Stress Responses and Cortisol(29), Nicotinic Acetylcholine Receptors Study(24), Receptor Mechanisms and Signaling(18)

Publications134 total

Phase 1 Clinical Results for NP10679, a pH‐sensitive GluN2B‐selective <i>N</i>‐methyl‐<scp>d</scp>‐aspartate Receptor Inhibitor
Clinical Pharmacology in Drug Development·2023· 8 citedOpen Access
A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B–Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use
Journal of Pharmacology and Experimental Therapeutics·2021· 14 citedOpen Access
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning
PLoS ONE·2017· 12 citedOpen Access
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents
European Journal of Pharmacology·2017· 21 cited
BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia
ACS Medicinal Chemistry Letters·2017· 13 citedOpen Access
Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR
Bioorganic & Medicinal Chemistry Letters·2017· 9 citedOpen Access
Development of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists
ACS Medicinal Chemistry Letters·2016· 12 citedOpen Access
Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship
Journal of Medicinal Chemistry·2016· 18 citedOpen Access
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia
PLoS ONE·2016· 30 citedOpen Access
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
Journal of Pharmacology and Experimental Therapeutics·2016· 118 citedOpen Access
N-Acetylaspartylglutamate: An endogenous peptide with high affinity for a brain "glutamate" receptor (neuropeptides/neurotransmitters/neuroexcitant)
2016
Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy
Neuropharmacology·2015· 18 cited
Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder
Molecular Psychiatry·2015· 178 citedOpen Access
Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors
ACS Medicinal Chemistry Letters·2014· 17 citedOpen Access
Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors
Nuclear Medicine and Biology·2014· 14 citedOpen Access
MK-801 disrupts and nicotine augments 40 Hz auditory steady state responses in the auditory cortex of the urethane-anesthetized rat
Neuropharmacology·2013· 58 cited
Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
Journal of Pharmacology and Experimental Therapeutics·2012· 63 cited
Pharmacological and behavioral characterization of the novel CRF1 antagonist BMS-763534
Neuropharmacology·2012· 2 cited
Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 6 citedOpen Access
Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex
The Journal of Physiology·2011· 102 citedOpen Access
page 1 of 7Next →

Frequent Co-authors

Joseph T. Coyle(14), Paul J. Gilligan(8), Lawrence W. Fitzgerald(7), Paul Hartig(6), David W. Robertson(6), Richard E. Olson(6), Joanne J. Bronson(6), Charles F. Albright(6), John E. Macor(6), Steven Culp(6), Yu-Wen Li(6), Harvey Wong(6), Snježana Lelas(6), Jere E. Meredith(5), Kimberley A. Lentz(5), George L. Trainor(5), Stephen P. Arnerić(4), Donna M. Barten(4), James E. Grace(4), John Mcelroy(4)