C. Edge

Age UK — United Kingdom

Engineering · Physical Sciences

21h-index1.4kcitations81works2.82yr avg
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Research Topics

Semiconductor Lasers and Optical Devices(22), Advanced Photonic Communication Systems(18), Photonic and Optical Devices(15), Optical Network Technologies(9), Protein Structure and Dynamics(8)

Publications81 total

Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors
RSC Medicinal Chemistry·2025Open Access
Crystal Structure Prediction of Drug Molecules in the Cloud: A Collaborative Blind Challenge Study
Crystal Growth & Design·2025· 4 citedOpen Access
A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition
Organic Letters·2024· 6 cited
CCDC 2093498: Experimental Crystal Structure Determination
The Cambridge Structural Database·2024Open Access
Synthesis of 2,6-<i>trans</i>-Tetrahydropyrans Using a Palladium-Catalyzed Oxidative Heck Redox-Relay Strategy
Organic Letters·2024· 4 citedOpen Access
Useful Computational Chemistry Tools for Medicinal Chemistry
2023
First global analysis of the GSK database of small molecule crystal structures
CrystEngComm·2021· 12 citedOpen Access
“Particle Informatics”: Advancing Our Understanding of Particle Properties through Digital Design
Crystal Growth & Design·2019· 26 cited
5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy
Bioorganic & Medicinal Chemistry Letters·2018· 14 citedOpen Access
Accelerating molecular discovery through data and physical sciences: Applications to peptide-membrane interactions
The Journal of Chemical Physics·2018· 14 cited
Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2018· 19 citedOpen Access
New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study
ACS Omega·2017· 16 citedOpen Access
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2017· 22 citedOpen Access
Decorating Self-Assembled Peptide Cages with Proteins
ACS Nano·2017· 61 cited
Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry
Acta Crystallographica Section D Structural Biology·2017· 61 citedOpen Access
Using 3D Structural Information in Computational Design
Elsevier eBooks·2017
Survival of the Fittest Computational Chemists, Computers, and Reference Works (Over a 30-Year Period)
Elsevier eBooks·2017
Latonduine Analogs Restore F508del–Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity
Molecular Pharmacology·2016· 25 cited
A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease Using RapidFire Mass Spectrometry
SLAS DISCOVERY·2015· 36 citedOpen Access
Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy
Crystal Growth & Design·2014· 65 citedOpen Access
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Frequent Co-authors

Michael J. Wale(11), Jonathan W. Essex(7), L.N. Langley(5), U. Gliese(5), A.J. Seeds(5), I. Bennion(5), Xuan Huang(4), Stephen Phillips(4), Luigi Stasi(4), Alastair D. Reith(4), M.D. Elkin(3), Xiao Ding(3), Kai Long(3), Zehong Wan(3), Yi Li(3), Xiao-Ming Guan(3), Feng Ren(3), A. Molony(2), B.D. Bax(2), Angela Bridges(2)