Keelan Z. Guiley

Howard Hughes Medical Institute — United States

Medicine · Health Sciences

12h-index1.2kcitations63works5.72yr avg
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Research Topics

Cancer-related Molecular Pathways(16), Ubiquitin and proteasome pathways(8), Protein Kinase Regulation and GTPase Signaling(6), Science, Research, and Medicine(6), Enzyme Structure and Function(5)

Publications63 total

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators
Cancer Discovery·2026Open Access
Supplementary Figure 3 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Figure 2 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Supplementary Figure 5 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Supplementary Figure 1 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Table S1 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Figure 1 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Figure 3 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Supplementary Figure 6 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Supplementary Figure 2 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Supplementary Figure 7 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Figure 4 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Supplementary Figure 4 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
2025Open Access
Abstract A096: Discovery of a covalent allosteric inhibitor targeting AKT1 E17K for the treatment of solid tumors
Molecular Cancer Therapeutics·2025
Abstract LB289: Clinical resistance to Y220C-mutant p53 reactivators
Cancer Research·2025
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket
Cell·2024· 37 citedOpen Access
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D
Nature Chemical Biology·2024· 65 citedOpen Access
Abstract C099: Mutant-selective, covalent inhibitors of K-Ras(G12D)
Cancer Research·2024
Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes
Analytical Chemistry·2023· 4 citedOpen Access
A foundational atlas of autism protein interactions reveals molecular convergence
2023· 20 citedOpen Access
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Frequent Co-authors

Kevan M. Shokat(28), Seth M. Rubin(16), Tilini U. Wijeratne(7), Larisa Litovchick(7), Sarvind Tripathi(6), Jessica Felthousen(6), Parameshwaran Ramanan(6), Ziyang Zhang(4), Tyler Liban(4), Gerd A. Müller(4), Audra N. Iness(3), Qinheng Zheng(3), Joseph S. Lipsick(3), Ali Bashir(3), Jack W. Stevenson(2), Kevin Lou(2), Krister J. Barkovich(2), Ian J. MacRae(2), Johannes Morstein(2), Varsha Ananthapadmanabhan(2)