K. N. Houk

University of North Carolina at Chapel Hill — United States

Materials Science · Physical Sciences

156h-index118.4kcitations2.6kworks11.42yr avg
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Research Topics

Crystallization and Solubility Studies(424), X-ray Diffraction in Crystallography(423), Asymmetric Synthesis and Catalysis(387), Organic Chemistry Cycloaddition Reactions(380), Catalytic C–H Functionalization Methods(237)

Publications2.6k total

Computational Explorations of Enzymes That Catalyze Ambimodal [4 + 2]/[6 + 4] Cycloadditions
Transformative Chemistry·2025· 1 citedOpen Access
Facile Access to Tricyclic Molecular Architectures through Photo-Reversible Dearomative 6π-Desymmetrizations: Scope, Applications, Bioactivity Study, and Mechanistic Nuances
Journal of the American Chemical Society·2025
Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states
Natural Product Reports·2025
Synthesis of Collinoketones via Biomimetic [6 + 4] Cycloaddition
Journal of the American Chemical Society·2025· 1 cited
Controlling pyramidal nitrogen chirality by asymmetric organocatalysis
Nature·2025· 3 cited
Reversible Room-Temperature Heterolytic Activation of Vinylic sp <sup>2</sup> C–H Bonds at a Gallium Center
Journal of the American Chemical Society·2025
Enzymatic Anti-Baldwin Ring-Closure Cascade for Fused Bicyclic Ether Formation
Journal of the American Chemical Society·2025· 1 cited
Gas-Phase-like Inertial Rotation of a Platonic Solid in Reticular Amphidynamic Crystals of CUB-5: Molecular Dynamics and Experiment
Journal of the American Chemical Society·2025
A Change in C–H Activation Mechanism: Experimental and Computational Investigations of Rh-Catalyzed Disubstituted Benzene Functionalization
Organometallics·2025Open Access
Molecular Dynamics of Cope Rearrangements of Substituted 1,5-Hexadienes: Variable Transition States and Mechanisms
The Journal of Organic Chemistry·2025· 1 cited
Biocatalytic, asymmetric radical hydrogenation of unactivated alkenes
Science·2025· 2 cited
WDR5 Binding to Histone Serotonylation Is Driven by an Edge-Face Aromatic Interaction with Unexpected Electrostatic Effects.
UNC Libraries·2025Open Access
Decoding the redox behaviour of copper in Ullmann-type coupling reactions
Nature·2025· 11 cited
Unraveling the Dichotomy Exerted by Boron Reagents in Site-Selective Functionalization of C(sp<sup>2</sup>)– and C(sp<sup>3</sup>)–OMe Bonds
Journal of the American Chemical Society·2025· 1 cited
Stereoselective Oxidative Coupling of Amino Acids or Oligopeptides with Aldehydes: A Mechanism Study
The Journal of Organic Chemistry·2025
Synthesis of Collinoketones via Biomimetic [6+4] Cycloaddition
2025
Synthesis of Collinoketones via Biomimetic [6+4] Cycloaddition
2025Open Access
Four-Component Reactions of [n.1.1]Propellanes (n = 1 or 3) Triggered by Electrophilic Activation
2025Open Access
Aspartic acid residues in BBE-like enzymes from <i>Morus alba</i> promote a function shift from oxidative cyclization to dehydrogenation
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Biocatalytic, Asymmetric Radical Hydrogenation of Unactivated Alkenes
2025Open Access
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Frequent Co-authors

David Baker(5), Steven E. Wheeler(4), Peng Liu(4), Jasmine L. Gallaher(3), Alexandre Zanghellini(3), Donald Hilvert(3), Daniel H. Ess(3), Gert Kiss(3), Sogole Bahmanyar(3), Benjamin List(3), Yun‐Fang Yang(3), Paul Ha‐Yeon Cheong(3), Nihan Çelebi‐Ölçüm(3), Daniela Röthlisberger(2), Lin Jiang(2), Jamie L. Betker(2), Eric A. Althoff(2), Yang Yang(2), Fernando R. Clemente(2), Barry Stoddard(2)