Thomas R. Vargo

Broad Institute — United States

Medicine · Health Sciences

7h-index297citations14works16.72yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(3), Crystallization and Solubility Studies(3), X-ray Diffraction in Crystallography(3), ATP Synthase and ATPases Research(3), Molecular Sensors and Ion Detection(2)

Publications14 total

Discovery of SARS-CoV-2 papain-like protease (PL <sup>pro</sup> ) inhibitors with efficacy in a murine infection model
Science Advances·2024· 38 citedOpen Access
Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response
2024· 7 citedOpen Access
Discovery of SARS-CoV-2 papain-like protease (PL <sup>pro</sup> ) inhibitors with efficacy in a murine infection model
2024· 5 citedOpen Access
Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
Journal of Medicinal Chemistry·2023· 9 citedOpen Access
Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody–Drug Conjugates
Bioconjugate Chemistry·2023· 11 cited
Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates
2023· 1 citedOpen Access
Catalytic Asymmetric Aldol Equivalents for an Enantioselective Total Synthesis of Apoptolidin C
D-Scholarship@Pitt (University of Pittsburgh)·2011Open Access
Catalytic Asymmetric Aldol Equivalents in the Enantioselective Synthesis of the Apoptolidin C Aglycone
Angewandte Chemie·2010· 4 cited
Catalytic Asymmetric Aldol Equivalents in the Enantioselective Synthesis of the Apoptolidin C Aglycone
Angewandte Chemie International Edition·2010· 28 cited
Quenching Mechanism of Zn(Salicylaldimine) by Nitroaromatics
Inorganic Chemistry·2008· 71 cited
Fluorescent Detection of Nitroaromatics and 2,3-Dimethyl- 2,3-dinitrobutane (DMNB) by a Zinc Complex:  (salophen)Zn
Inorganic Chemistry·2007· 123 cited
CCDC 652674: Experimental Crystal Structure Determination
The Cambridge Structural Database·2007Open Access
CCDC 652672: Experimental Crystal Structure Determination
The Cambridge Structural Database·2007Open Access
CCDC 652673: Experimental Crystal Structure Determination
The Cambridge Structural Database·2007Open Access

Frequent Co-authors

Michael J. Knapp(5), Peter G. Khalifah(4), Matthew C. Robinson(3), Alpha A. Lee(3), M.E. Germain(3), Meaghan E. Germain(2), Michelle R. Garnsey(2), Luong T. Nguyen(2), Rhonda D. Cardin(2), Joseph Tillotson(2), Ellene H. Mashalidis(2), Aijia Yu(2), Lisa Aschenbrenner(2), Amanda Balesano(2), Britton Boras(2), Jeanne S. Chang(2), Heather Eng(2), Andrew Ephron(2), Kristen K. Ford(2), James M. Frick(2)