Thierry Bertomeu

Institute for Research in Immunology and Cancer — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.1kcitations59works0.42yr avg
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Research Topics

Protein Degradation and Inhibitors(8), Acute Myeloid Leukemia Research(6), CRISPR and Genetic Engineering(6), Ubiquitin and proteasome pathways(6), Protist diversity and phylogeny(5)

Publications59 total

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2026Open Access
Author response: Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2026Open Access
Reviewer #2 (Public review): Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2026Open Access
Reviewer #1 (Public review): Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2026Open Access
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture
2026Open Access
CRISPR-based chemogenomic profiling reveals redox vulnerabilities to epigallocatechin-3-gallate and green tea polyphenol extract
Redox Biology·2026Open Access
The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition
2025Open Access
A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept
2025Open Access
On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions
2025· 2 citedOpen Access
Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts
Frontiers in Cell and Developmental Biology·2025· 1 citedOpen Access
CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity
Proceedings of the National Academy of Sciences·2025Open Access
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2025Open Access
Author response: Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2025Open Access
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2025Open Access
Abstract 2819: Metabolic determinants of ferroptosis in B-cell malignancies
Cancer Research·2025
Metabolic Determinants of Ferroptosis in B-Cell Lymphoma
Blood·2024· 3 cited
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
2024Open Access
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
Molecular Cell·2023· 45 citedOpen Access
Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations
PLoS Genetics·2023· 13 citedOpen Access
Abstract 2635: Targeting virus-induced vulnerabilities using synthetic lethality as a new class of host-based antivirals
Journal of Biological Chemistry·2023Open Access
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Frequent Co-authors

Mike Tyers(26), Jasmin Coulombe‐Huntington(22), Roya Khosravi‐Far(9), Andrew Chatr‐aryamontri(8), Tara MacRae(7), Pierre Thibault(7), Anne Marinier(7), Guy Sauvageau(7), Caroline Huard(7), David Papadopoli(7), Bernhard Lehnertz(6), Jean-François Spinella(6), Nadine Mayotte(6), Geneviève Boucher(6), Sébastien Lemieux(6), Josée Hébert(6), David Morse(6), Bodvaël Pennarun(6), Octavian Bucur(6), Daina Avizonis(6)