Raimo K. Tuominen

University of Helsinki — Finland

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index4.1kcitations189works12.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(34), Nicotinic Acetylcholine Receptors Study(25), Neuroscience and Neuropharmacology Research(23), Protein Kinase Regulation and GTPase Signaling(23), Nerve injury and regeneration(21)

Publications188 total

Biomarkers of Parkinson's disease in perspective of early diagnosis and translation of neurotrophic therapies
Basic & Clinical Pharmacology & Toxicology·2024· 12 citedOpen Access
Biomarkers of Parkinson's disease in perspective of early diagnosis and translation of neurotrophic therapies
2023Open Access
Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists
Journal of Medicinal Chemistry·2023· 4 citedOpen Access
Protein Kinase A–Mediated Effects of Protein Kinase C Partial Agonist 5-(Hydroxymethyl)Isophthalate 1a3 in Colorectal Cancer Cells
Journal of Pharmacology and Experimental Therapeutics·2021· 4 citedOpen Access
Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats
Journal of Parkinson s Disease·2021· 23 citedOpen Access
GDNF Receptor Agonist Alleviates Motor Imbalance in Unilateral 6-Hydroxydopamine Model of Parkinson's Disease.
PubMed·2020· 3 citedOpen Access
Rigorous Computational Study Reveals What Docking Overlooks: Double Trouble from Membrane Association in Protein Kinase C Modulators
Journal of Chemical Information and Modeling·2020· 8 citedOpen Access
Porvoonväylän (Vt 7) Länsimäentien pysäkit : Aluevaraussuunnitelma, Vantaa, Helsinki
Doria (University of Helsinki)·2020
Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics
ACS Medicinal Chemistry Letters·2019· 8 citedOpen Access
Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons <i>In Vitro</i> and Enhances Dopamine Release <i>In Vivo</i>
Movement Disorders·2019· 38 citedOpen Access
Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke
Biomaterials·2019· 29 citedOpen Access
A potent partial agonist of PKC orients in membranes like the biological activator diacylglycerol
Työväentutkimus Vuosikirja·2019Open Access
GDNF receptor agonist supports dopamine neurons in vitro and protects their function in animal model of Parkinson’s
2019· 6 citedOpen Access
Rat subthalamic stimulation: Evaluating stimulation-induced dyskinesias, choosing stimulation currents and evaluating the anti-akinetic effect in the cylinder test
MethodsX·2019· 7 citedOpen Access
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease
Journal of Neuroscience Research·2018· 30 citedOpen Access
Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations
Neuropharmacology·2018· 15 citedOpen Access
Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease
Frontiers in Neurology·2018· 29 citedOpen Access
Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C
PLoS ONE·2018· 9 citedOpen Access
Anticancer activity of the protein kinase C modulator <scp>HMI</scp>‐1a3 in 2D and 3D cell culture models of androgen‐responsive and androgen‐unresponsive prostate cancer
FEBS Open Bio·2018· 10 citedOpen Access
Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson’s Disease
Neuroscience·2018· 28 citedOpen Access
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Frequent Co-authors

Merja H. Voutilainen(11), Märt Saarma(11), Pekka T. Männistö(9), Susanne Bäck(7), Mikko Airavaara(7), Elina Ekokoski(7), Virpi Talman(6), Päivi Lindholm(5), Andrii Domanskyi(5), Jari Yli‐Kauhaluoma(5), Petteri Piepponen(5), Johan Peränen(4), Atso Raasmaja(4), Jau‐Shyong Hong(4), Juho‐Matti Renko(4), Gustav Boije af Gennäs(4), Petri J. Vainío(4), Kid Törnquist(4), Maria Lindahl(3), Brandon K. Harvey(3)