Yuri V. Sergeev

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index5.4kcitations191works4.12yr avg
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Research Topics

Retinal Development and Disorders(49), melanin and skin pigmentation(40), Connexins and lens biology(34), Biochemical Analysis and Sensing Techniques(28), RNA regulation and disease(28)

Publications191 total

Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of Hypopigmentation
2025Open Access
Genetic mutations disrupt the coordinated mode of tyrosinase's intra‐melanosomal domain
Protein Science·2025· 5 citedOpen Access
Age‐Dependent Histone Deacetylase 3 Regulation by <scp>βA3</scp>/<scp>A1</scp>‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration
Aging Cell·2025· 1 citedOpen Access
Variants in NR6A1 cause a novel oculo vertebral renal syndrome
Nature Communications·2025· 7 citedOpen Access
Genetic mutations disrupt the coordinated mode of tyrosinase intra-melanosomal domain
2025Open Access
Human recombinant tyrosinase destabilization caused by the double mutation <scp>R217Q</scp>/<scp>R402Q</scp>
Protein Science·2025· 3 citedOpen Access
Variants in NR6A1 cause a novel oculo-vertebral-renal (OVR) syndrome
2024Open Access
Variants in NR6A1 cause a novel oculo-vertebral-renal (OVR) syndrome
2024· 2 citedOpen Access
Linking Protein Stability to Pathogenicity: Predicting Clinical Significance of Single-Missense Mutations in Ocular Proteins Using Machine Learning
International Journal of Molecular Sciences·2024Open Access
βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells
2024· 1 citedOpen Access
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
Nature Communications·2024· 23 citedOpen Access
Neuropathy target esterase activity defines phenotypes among <i>PNPLA6</i> disorders
Brain·2024· 7 citedOpen Access
Molecular Modeling of the Multiple-Substrate Activity of the Human Recombinant Intra-Melanosomal Domain of Tyrosinase and Its OCA1B-Related Mutant Variant P406L
International Journal of Molecular Sciences·2024· 8 citedOpen Access
Inherited Eye Disease-Related Proteins: Molecular Modeling and Global Computational Mutagenesis
Essentials in ophthalmology/Essentials ophthalmology·2024
Evaluating the Cysteine-Rich and Catalytic Subdomains of Human Tyrosinase and OCA1-Related Mutants Using 1 μs Molecular Dynamics Simulation
International Journal of Molecular Sciences·2023· 6 citedOpen Access
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD
2023· 3 citedOpen Access
Haplotype-based analysis resolves missing heritability in oculocutaneous albinism type 1B
The American Journal of Human Genetics·2023· 19 citedOpen Access
Neuropathy target esterase activity predicts retinopathy among <i>PNPLA6</i> disorders
2023· 1 citedOpen Access
Ultra-rare complement factor 8 coding variants in families with age-related macular degeneration
iScience·2023· 8 citedOpen Access
In Vitro Reconstitution of the Melanin Pathway’s Catalytic Activities Using Tyrosinase Nanoparticles
International Journal of Molecular Sciences·2022· 4 citedOpen Access
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Frequent Co-authors

J. Fielding Hejtmancik(15), Paul T. Wingfield(10), Monika B. Dolinska(8), Anand Swaroop(6), Stacey Hose(6), Rhonda Grebe(6), Debasish Sinha(6), J. Samuel Zigler(5), James T. Handa(5), Imran Ahmed Bhutto(5), Gerard A. Lutty(5), Brian P. Brooks(5), Paul A. Sieving(5), Qingjiong Zhang(4), Robert N. Fariss(4), Sheikh Riazuddin(4), Rafael C. Caruso(4), Ian M. MacDonald(4), Xiaodong Jiao(3), Wenliang Yao(3)