Giacomo Cossa

University of Würzburg — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.2kcitations33works7.12yr avg
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Research Topics

RNA Research and Splicing(7), Drug Transport and Resistance Mechanisms(6), Ubiquitin and proteasome pathways(4), MicroRNA in disease regulation(3), RNA modifications and cancer(3)

Publications33 total

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids
Cell·2026· 2 citedOpen Access
The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma
Genes & Development·2025· 2 citedOpen Access
RNA-mediated MYC multimerization suppresses innate immune signaling
2024· 1 citedOpen Access
A trimeric USP11/USP7/TCEAL1 complex stabilizes RNAPII during early transcription to sustain oncogenic gene expression
2024· 1 citedOpen Access
The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
Molecular Cell·2024· 15 citedOpen Access
PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
Nature Communications·2024· 9 citedOpen Access
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts
Nucleic Acids Research·2024· 20 citedOpen Access
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts
2023· 2 citedOpen Access
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription
Molecular Cell·2021· 7 citedOpen Access
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets
Genes & Development·2021· 69 citedOpen Access
Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
Molecular Cell·2020· 62 citedOpen Access
PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells
Toxicology and Applied Pharmacology·2016· 48 cited
Abstract 1257: A MYC-Aurka protein complex represents an actionable target in p53 altered liver cancer
Cancer Research·2016
A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
Nature Medicine·2016· 263 cited
Targeting the invasive phenotype of cisplatin-resistant Non-Small Cell Lung Cancer cells by a novel histone deacetylase inhibitor
Biochemical Pharmacology·2015· 20 cited
Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells
Cancer Letters·2014· 34 cited
Improved Apoptotic Cell Death in Drug-Resistant Non–Small-Cell Lung Cancer Cells by Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Based Treatment
Journal of Pharmacology and Experimental Therapeutics·2013· 30 cited
Abstract A93: Targeting the increased invasive capability of non-small cell lung cancer platinum-resistant cells by histone deacetylase inhibitors.
Molecular Cancer Therapeutics·2013
Modulation of Sensitivity to Antitumor Agents by Targeting the MAPK Survival Pathway
Current Pharmaceutical Design·2012· 47 cited
Modulation of Sensitivity to Antitumor Agents by Targeting the MAPK Survival Pathway
Current Pharmaceutical Design·2012· 46 cited
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Frequent Co-authors

Paola Perego(18), Laura Gatti(17), Martin Eilers(11), Nadia Zaffaroni(10), Franco Zunino(8), Giovanni Luca Beretta(7), Carsten P. Ade(7), Giuliana Cassinelli(7), Cinzia Lanzi(7), Peter Gallant(7), Nives Carenini(6), Christina Schülein‐Völk(6), Elisabetta Corna(5), Raphael Vidal(5), Seychelle M. Vos(5), Apoorva Baluapuri(4), Elmar Wolf(4), Stella Tinelli(4), Daniel Solvie(4), Monica Tortoreto(3)