William H. Tepp

University of Wisconsin–Madison — United States

Medicine · Health Sciences

40h-index6.6kcitations128works1.82yr avg
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Research Topics

Botulinum Toxin and Related Neurological Disorders(117), Neurological disorders and treatments(91), Hereditary Neurological Disorders(57), Parkinson's Disease Mechanisms and Treatments(10), Biochemical and Structural Characterization(10)

Publications128 total

The Membrane Localization Domain (MLD) of Botulinum Neurotoxin A1 is Essential for Its Long Duration of Action
Toxicon·2026
Botulinum Neurotoxins: A Distinct Subclass of SNARE-Cleaving Endopeptidases
Toxicon·2026
Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25
Communications Biology·2025· 1 citedOpen Access
Nontoxic, multi-domain botulinum neurotoxin-LCHCN as vaccines against botulism.
Vaccine·2025· 1 citedOpen Access
Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site
Journal of Medicinal Chemistry·2025
Expression of Recombinant Clostridial Neurotoxin by C. tetani
Microorganisms·2024Open Access
Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies
ACS Infectious Diseases·2024· 3 citedOpen Access
Potency Evaluations of Recombinant Botulinum Neurotoxin A1 Mutants Designed to Reduce Toxicity
International Journal of Molecular Sciences·2024· 5 citedOpen Access
Botulinum neurotoxin X lacks potency in mice and in human neurons
mBio·2024· 10 citedOpen Access
Neurotoxicity of a Botulinum-Like Toxin Homolog From Enterococcus
Toxicon·2024
Toxicity Evaluations of Botulinum Neurotoxin A1 Mutants Designed to be Atoxic
Toxicon·2024
Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain
International Journal of Molecular Sciences·2023· 3 citedOpen Access
Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease
International Journal of Molecular Sciences·2023· 4 citedOpen Access
Genomic Diversity, Competition, and Toxin Production by Group I and II Clostridium botulinum Strains Used in Food Challenge Studies
Microorganisms·2022· 8 citedOpen Access
Investigation of Salicylanilides as Botulinum Toxin Antagonists
ACS Infectious Diseases·2022· 4 citedOpen Access
Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane
Toxicon·2022
Cultured Human-Induced Pluripotent Stem Cell–Derived Motor Neurons as a Sensitive Model for BoNT Detection
Toxicon·2022
Botulinum Neurotoxin X Lacks Potency in Mice and in Human Neurons
Toxicon·2022
Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane
International Journal of Molecular Sciences·2021· 6 citedOpen Access
Posttranslational Regulation of Botulinum Neurotoxin Production in Clostridium botulinum Hall A- <i>hyper</i>
mSphere·2021· 8 citedOpen Access
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Frequent Co-authors

Eric A. Johnson(47), Sabine Pellett(13), Min Dong(12), Christina L. Pier(12), Edwin R. Chapman(9), Marite Bradshaw(9), Guangyun Lin(7), Joseph Barbieri(7), Raymond C. Stevens(5), Huisheng Liu(5), Regina C. M. Whitemarsh(5), Michael C. Goodnough(4), Lisheng Peng(4), Mark J. Jacobson(4), Michael R. Baldwin(4), David J. Beebe(4), Felix L. Yeh(3), Bibhuti R. DasGupta(3), C.M. Forsyth(3), James D. Marks(3)