Taran Khanam

Medicine · Health Sciences

6h-index98citations13works0.02yr avg
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Research Topics

Tuberculosis Research and Epidemiology(6), DNA Repair Mechanisms(5), Cancer therapeutics and mechanisms(5), Bacterial Genetics and Biotechnology(3), Antibiotic Resistance in Bacteria(3)

Publications13 total

Abstract B053: Discovery of an allosteric, potent and selective DHX9 helicase inhibitor with best-in-class potential for the treatment of genomically unstable cancers
Molecular Cancer Therapeutics·2025
Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex
International Journal of Biological Macromolecules·2022
<i>Mycobacterium tuberculosis</i> Endonuclease VIII 2 (Nei2) forms a prereplicative BER complex with DnaN: Identification, characterization, and disruption of complex formation
Molecular Microbiology·2021· 6 cited
CDKL5 kinase controls transcription‐coupled responses to DNA damage
The EMBO Journal·2021· 31 citedOpen Access
Epilepsy kinase CDKL5 is a DNA damage sensor which controls transcriptional activity at DNA breaks
2020Open Access
CDKL5_Data_Analysis_Phospho-TMT
Zenodo (CERN European Organization for Nuclear Research)·2020Open Access
OUP accepted manuscript
Nucleic Acids Research·2020· 4 citedOpen Access
<i>Mycobacterium tuberculosis</i> class <scp>II</scp> apurinic/apyrimidinic‐endonuclease/3′‐5′ exonuclease <scp>III</scp> exhibits <scp>DNA</scp> regulated modes of interaction with the sliding <scp>DNA</scp> β‐clamp
Molecular Microbiology·2015· 8 cited
Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3′–5′ exonuclease III
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2015· 4 cited
Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I
Organic & Biomolecular Chemistry·2015· 16 cited
Exploiting Bacterial DNA Repair Systems as Drug Targets: A Review of the Current Scenario with Focus on Mycobacteria
2014· 6 cited
M. tuberculosis Sliding β-Clamp Does Not Interact Directly with the NAD+ -Dependent DNA Ligase
PLoS ONE·2012· 18 citedOpen Access
Synthesis and bioevaluation of aryl hydroxamates distinguishing between NAD+ and ATP-dependent DNA ligases
MedChemComm·2012· 5 cited

Frequent Co-authors

Ravishankar Ramachandran(8), Ankita Shukla(4), Iván Muñoz(3), Florian Weiland(3), Thomas Carroll(3), Barbara N. Borsos(3), Vasiliki Pantazi(3), Meghan M. Slean(3), Miroslav Novák(3), Rachel Toth(3), Paul L. Appleton(3), Tibor Pankotai(3), Houjiang Zhou(3), John Rouse(3), Niyati Rai(3), Sanjay Kumar(3), Michael Morgan(2), Vandna Kukshal(2), Mohammad Afsar(2), Deepti Chopra(1)