Isaac Canals

Lund University — Sweden

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index651citations34works1.42yr avg
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Research Topics

Pluripotent Stem Cells Research(13), CRISPR and Genetic Engineering(10), Glioma Diagnosis and Treatment(6), Mitochondrial Function and Pathology(5), Neurogenesis and neuroplasticity mechanisms(5)

Publications33 total

Supplementary Data from Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth <i>In Vitro</i> and <i>In Vivo</i>
2025Open Access
Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders
eNeuro·2025Open Access
Rapid and efficient generation of human oligodendrocytes myelinating adult human cortical neurons
2025· 1 citedOpen Access
Aberrant neurodevelopment in human <scp>iPS</scp> cell‐derived models of Alexander disease
Glia·2024· 5 citedOpen Access
Data from Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2024Open Access
Data from Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
Supplementary Data from Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
Supplementary Data from Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Brain Communications·2023· 10 citedOpen Access
Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth <i>In Vitro</i> and <i>In Vivo</i>
Molecular Cancer Therapeutics·2022· 10 citedOpen Access
FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis
Frontiers in Cell and Developmental Biology·2022· 5 citedOpen Access
Transcription factor-based direct conversion of human fibroblasts to functional astrocytes
Stem Cell Reports·2022· 30 citedOpen Access
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence
EMBO Reports·2021· 24 citedOpen Access
Transcription Factor-Based Strategies to Generate Neural Cell Types from Human Pluripotent Stem Cells
Cellular Reprogramming·2021· 12 cited
NGN2 mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities
Frontiers in Cellular Neuroscience·2021· 15 citedOpen Access
CRISPR/Cas9 Genome Engineering in Human Pluripotent Stem Cells for Modeling of Neurological Disorders
Methods in molecular biology·2021· 5 cited
Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons
Methods in molecular biology·2021· 8 cited
Genome Editing Using Cas9-gRNA Ribonucleoprotein in Human Pluripotent Stem Cells for Disease Modeling
Methods in molecular biology·2021
Sanfilippo Syndrome: Molecular Basis, Disease Models and Therapeutic Approaches
International Journal of Molecular Sciences·2020· 51 citedOpen Access
3118 – METABOLIC REGULATION OF LINEAGE SPECIFICATION DURING ENDOTHELIAL TO HEMATOPOIETIC TRANSITION
Experimental Hematology·2020
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Frequent Co-authors

Henrik Ahlenius(20), Johan Bengzon(10), Oskar G. Zetterdahl(10), Lluı̈sa Vilageliu(9), Daniel Grinberg(9), Francesco Trovato(7), Ella Quist(6), Marita Grønning Hansen(6), Noelia Benetó(6), Francesca Romana Stefani(6), Jiaxin Li(6), Emanuela Monni(4), Isabel Hidalgo(4), Mónica Cozar(4), Leal Oburoglu(4), Aurélie Ginisty(3), Raissa Timmerman(3), Jonas Fritze(3), Giedre Miskinyte(3), David Bryder(3)