Joice Thomas

University of Richmond — United States

Chemistry · Physical Sciences

32h-index3.3kcitations138works4.32yr avg
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Research Topics

Click Chemistry and Applications(32), Crystallization and Solubility Studies(31), X-ray Diffraction in Crystallography(31), Chemical Synthesis and Analysis(24), Crystallography and molecular interactions(16)

Publications137 total

Discovery and Characterization of Potent, Selective, and Orally Bioavailable 7-Azaindazole AXL Receptor Tyrosine Kinase Inhibitors
Journal of Medicinal Chemistry·2025· 3 cited
Discovery of AB801, a Potent and Selective Inhibitor of AXL Receptor Tyrosine Kinase for Use in Cancer Therapy
Journal of Medicinal Chemistry·2025
Synthesis, Structure, and Reactivity of Copper(I) Proazaphosphatrane Complexes
Inorganic Chemistry·2025Open Access
Abstract A011: Discovery and characterization of the first highly potent and selective AXL receptor tyrosine kinase inhibitor AB801
Molecular Cancer Therapeutics·2024
Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target
ACS Chemical Biology·2024· 22 citedOpen Access
Discovery of a novel androgen receptor antagonist, MEL-6, with stereoselective activity and optimization of its metabolic stability
The Journal of Steroid Biochemistry and Molecular Biology·2024· 1 citedOpen Access
Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
Molecules·2022· 8 citedOpen Access
854 HPK1 inhibition relieves suppression downstream of TCR activation to drive enhanced cytokine production and antigen-specific killing, an effect that is further enhanced by immune checkpoint blockade
Regular and Young Investigator Award Abstracts·2022Open Access
Abstract 1367: HPK1 inhibition enhances T cell activation and relieves the immunosuppressive phenotype of inhibitory signals found in the tumor microenvironment
Cancer Research·2022· 1 cited
CCDC 2076357: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
CCDC 2076359: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
CCDC 2076360: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
CCDC 2076358: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
DNA-SIP and repeated isolation corroborate <i>Variovorax</i> as a key organism in maintaining the genetic memory for linuron biodegradation in an agricultural soil
FEMS Microbiology Ecology·2021· 4 cited
Synthesis of homochiral sulfanyl- and sulfoxide-substituted naphthyltriazoles and study of the conformational stability
Organic & Biomolecular Chemistry·2021· 8 citedOpen Access
Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonuclease
2020· 6 cited
DNA-SIP and repeated isolation corroborate <i>Variovorax</i> as a key organism in maintaining the genetic memory for linuron biodegradation in an agricultural soil
2020Open Access
Culture-Independent Analysis of Linuron-Mineralizing Microbiota and Functions in on-Farm Biopurification Systems via DNA-Stable Isotope Probing: Comparison with Enrichment Culture
Environmental Science & Technology·2020· 30 citedOpen Access
Pharmacological and Ischemic Preconditioning Up-Regulate the Expression of Socs in Adult Cardiac Myocytes: Its Physiological Significance
Biophysical Journal·2019Open Access
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Frequent Co-authors

Wim Dehaen(39), Mario Smet(17), Sampad Jana(7), Sandra Liekens(7), Luc Van Meervelt(7), Bert F. Sels(6), Jubi John(6), Wouter Maes(6), G P Mannaerts(4), Luc J. Debeer(4), Stijn Van de Vyver(4), Feng Yu(4), Mahendra P. Sonawane(4), P.J. De Schepper(3), Jan Geboers(3), Nikita Parekh(3), Wim Van Rossom(3), Kristof Van Hecke(3), Koen Robeyns(3), S.-F. Koelewijn(2)