Khaja Azhar Hussain

Purdue University West Lafayette — United States

Medicine · Health Sciences

13h-index1.0kcitations25works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(10), Chemical Synthesis and Analysis(8), Asymmetric Synthesis and Catalysis(6), Synthetic Organic Chemistry Methods(6), Carbohydrate Chemistry and Synthesis(5)

Publications25 total

Design, Synthesis and X-ray Structure of Protein−Ligand Complexes:  Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors
Journal of the American Chemical Society·2006· 57 citedOpen Access
Altered HIV-1 Gag Protein Interactions with Cyclophilin A (CypA) on the Acquisition of H219Q and H219P Substitutions in the CypA Binding Loop
Journal of Biological Chemistry·2005· 52 citedOpen Access
Structure-Based Design:  Synthesis and Biological Evaluation of a Series of Novel Cycloamide-Derived HIV-1 Protease Inhibitors
Journal of Medicinal Chemistry·2005· 61 citedOpen Access
Novel Cyclourethane‐Derived HIV Protease Inhibitors: A Ring‐Closing Olefin Metathesis Based Strategy.
ChemInform·2002
Novel cyclourethane-Derived HIV protease inhibitors: A ring-closing olefin metathesis based strategy
Bioorganic & Medicinal Chemistry Letters·2002· 13 citedOpen Access
Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease
Antiviral Research·2002· 29 cited
A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site
Journal of Virology·2002· 138 citedOpen Access
Structure-Based Design:  Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)
Journal of Medicinal Chemistry·2001· 224 citedOpen Access
ChemInform Abstract: Structure‐Based Design of Non‐Peptide HIV Protease Inhibitors
ChemInform·2001· 1 cited
ChemInform Abstract: Convenient Synthesis of Novel Macrocyclic Urethanes: Alkoxycarbonylation of Amines and Ring‐Closing Metathesis Strategy.
ChemInform·1998
Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy
Tetrahedron Letters·1998· 23 citedOpen Access
Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere
Bioorganic & Medicinal Chemistry Letters·1998· 155 citedOpen Access
ChemInform Abstract: Asymmetric Aldol Route to Hydroxyethylamine Isostere: Stereoselective Synthesis of the Core Unit of Saquinavir.
ChemInform·1998
ChemInform Abstract: Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of syn‐ and anti‐Aldols.
ChemInform·1998
Ester derived titanium enolate aldol reaction: Highly diastereoselective synthesis of syn- and anti-aldols
Tetrahedron Letters·1997· 44 citedOpen Access
Asymmetric Aldol Route to Hydroxyethylamine Isostere:  Stereoselective Synthesis of the Core Unit of Saquinavir
The Journal of Organic Chemistry·1997· 35 citedOpen Access
ChemInform Abstract: Synthesis of a Peptidomimetic Analogue of the Binding Domain of Rapamycin.
ChemInform·1997
Synthesis of a Peptidomimetic Analog of the Binding Domain of Rapamycin
Chemistry Letters·1997· 2 cited
Synthesis of rapamycin-peptide hybrid molecule (RAP-P): High affinity FKBP12 ligand
Tetrahedron·1996· 1 cited
ChemInform Abstract: α‐Phenylglycinol as Chiral Auxiliary in the Diastereoselective Strecker Synthesis of α‐Amino Acids.
ChemInform·1995
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Frequent Co-authors

Arun K. Ghosh(15), Tushar Kanti Chakraborty(8), D. Eric Walters(5), L E Holland(4), Jim Buthod(4), Lisa Swanson(4), Steve Fidanze(4), Hanna Cho(3), Hiroaki Mitsuya(3), G. V. REDDY(3), Geoffrey Bilcer(2), Dong-Woo Shin(2), Hong Lin(2), Gerald Koelsch(2), Jordan Tang(2), K. Krishnan(2), Hanna Cho(2), M. ONISHI(2), Chunfeng Liu(2), D. Thippeswamy(2)